Evidence map›Paper›PMID 24906849›Full record

ArticleInternational journal of clinical oncology2015

Opioid needs of terminally ill patients with gynecologic malignancies.

Fumi Utsumi, Hiroaki Kajiyama, Jun Sakata, Makiko Higashi, Kaoru Niimi, Ryuichiro Sekiya, Hiroko Mitsui, Shiro Suzuki, Tomokazu Umezu, Mika Mizuno and 3 more

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Article in International journal of clinical oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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13 authors.

Fumi UtsumiDepartment of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsuruma-cho 65, Showa-ku, Nagoya, 466-8550, Japan.
Hiroaki Kajiyama
Jun Sakata
Makiko Higashi
Kaoru Niimi
Ryuichiro Sekiya
Hiroko Mitsui
Shiro Suzuki
Tomokazu Umezu
Mika Mizuno
Eiko Yamamoto
Kiyosumi Shibata
Fumitaka Kikkawa

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLittle is known about patterns and predictive factors regarding opioid use for terminally ill patients with gynecologic malignancies. The aim of this study was to elucidate predictors affecting opioid requirements of end-of-life patients with gynecologic malignancies.

methodsA retrospective study was carried out on patients with gynecological malignancies admitted to our institute and died during the years 2002 to 2012. The association between maximum opioid dose and factors affecting opioid requirements were examined. Data extracted from medical records included age, site of primary cancer, maximum total dose of opioids prescribed over 24 h, the site of recurrence and metastasis, procedures performed during the hospital stay, total number of chemotherapy courses and overall survival.

resultsThe study identified 189 patients. Most patients had ovarian cancer (42.3 %) followed by cervical cancer (28.0 %) and then corpus malignancy (27.0 %). Opioid requirements decreased with increasing age, especially from the 50s onward. This was particularly marked in cervical cancer patients. In addition, pelvic metastasis was associated with the maximum dose of opioids and the average opioid use was highest in patients with cervical cancer.

conclusionYoung age and pelvic invasion were significant predictive factors regarding opioid requirements. Additionally, cervical cancer patients may require more opioids among those with gynecologic malignancies.

Indexed as

Terminal CareAge FactorsAnalgesics, OpioidFemaleGenital Neoplasms, FemaleHumansMiddle AgedNeoplasm InvasivenessNeoplasm MetastasisOvarian NeoplasmsPainPelvisRetrospective StudiesRisk FactorsUterine Cervical NeoplasmsVaginal NeoplasmsAnalgesics, Opioid

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.