ArticleClinical orthopaedics and related research2014
CORR® ORS Richard A. Brand Award for Outstanding Orthopaedic Research: Engineering flexor tendon repair with lubricant, cells, and cytokines in a canine model.
Article in Clinical orthopaedics and related research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Solid-Liquid Interface Lubricating Hydrogels for Tendon-Bone Healing.Research (Washington, D.C.) · 2025Article
- Mesenchymal Stromal Cells for the Enhancement of Surgical Flexor Tendon Repair in Animal Models: A Systematic Review and Meta-Analysis.Bioengineering (Basel, Switzerland) · 2024Review
- A Novel Bi-Directional and Bi-Temporal Delivery System for Enhancing Intrasynovial Tendon Repair.Materials and interfaces · 2024Article
- Preclinical tendon and ligament models: Beyond the 3Rs (replacement, reduction, and refinement) to 5W1H (why, who, what, where, when, how).Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Review
- Motion lubrication suppressed mechanical activation via hydrated fibrous gene patch for tendon healing.Science advances · 2023Article
- Regulating Blood Clot Fibrin Films to Manipulate Biomaterial-Mediated Foreign Body Responses.Research (Washington, D.C.) · 2023Article
- Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity.Nature biomedical engineering · 2022Article
- Characterization of scar tissue biomechanics during adult murine flexor tendon healing.Journal of the mechanical behavior of biomedical materials · 2022Article
- An In Vivo Comparison: Novel Mesh Suture Versus Traditional Suture-Based Repair in a Rabbit Tendon Model.Journal of hand surgery global online · 2022Article
- Intrinsic Tendon Regeneration After Application of Purified Exosome Product: An In Vivo Study.Orthopaedic journal of sports medicine · 2021Article
- The Effect of Growth Differentiation Factor 8 (Myostatin) on Bone Marrow-Derived Stem Cell-Coated Bioactive Sutures in a Rabbit Tendon Repair Model.Hand (New York, N.Y.) · 2020Article
- Combined Administration of ASCs and BMP-12 Promotes an M2 Macrophage Phenotype and Enhances Tendon Healing.Clinical orthopaedics and related research · 2017Article
- A review on animal models and treatments for the reconstruction of Achilles and flexor tendons.Journal of materials science. Materials in medicine · 2017Review
- Murine Flexor Tendon Injury and Repair Surgery.Journal of visualized experiments : JoVE · 2016Article
- Cell and Biologic-Based Treatment of Flexor Tendon Injuries.Operative techniques in orthopaedics · 2016Article
- Effect of adipose-derived stromal cells and BMP12 on intrasynovial tendon repair: A biomechanical, biochemical, and proteomics study.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2016Article
- Effects of lubricant and autologous bone marrow stromal cell augmentation on immobilized flexor tendon repairs.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2016Article
- Mechanisms of tendon injury and repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2015Review
- Tenogenically differentiated adipose-derived stem cells are effective in Achilles tendon repair in vivo.Journal of tissue engineeringArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAdhesions and poor healing are complications of flexor tendon repair. QUESTIONS/PURPOSES: The purpose of this study was to investigate a tissue engineering approach to improve functional outcomes after flexor tendon repair in a canine model.
methodsFlexor digitorum profundus tendons were lacerated and repaired in 60 dogs that were followed for 10, 21, or 42 days. One randomly selected repair from either the second or fifth digit in one paw in each dog was treated with carbodiimide-derivatized hyaluronic acid, gelatin, and lubricin plus autologous bone marrow stromal cells stimulated with growth and differentiation factor 5; control repair tendons were not treated. Digits were analyzed by adhesion score, work of flexion, tendon-pulley friction, failure force, and histology.
resultsIn the control group, 35 of 52 control tendons had adhesions, whereas 19 of 49 treated tendons had adhesions. The number of repaired tendons with adhesions in the control group was greater than the number in the treated group at all three times (p = 0.005). The normalized work of flexion in treated tendons was 0.28 (± 0.08), 0.29 (± 0.19), and 0.32 (± 0.22) N/mm/° at Day 10, Day 21, and Day 42 respectively, compared with the untreated tendons of 0.46 (± 0.19) at Day 10 (effect size, 1.5; p = 0.01), 0.77 (± 0.49) at Day 21 (effect size, 1.4; p < 0.001), and 1.17 (± 0.82) N/mm/° at Day 42 (effect size, 1.6; p < 0.001). The friction data were comparable to the work of flexion data at all times. The repaired tendon failure force in the untreated group at 42 days was 70.2 N (± 8.77), which was greater than the treated tendons 44.7 N (± 8.53) (effect size, 1.9; p < 0.001). Histologically, treated repairs had a smooth surface with intrinsic healing, whereas control repairs had surface adhesions and extrinsic healing.
conclusionsOur study provides evidence that tissue engineering coupled with restoration of tendon gliding can improve the quality of tendon healing in a large animal in vivo model. CLINICAL RELEVANCE: Tissue engineering may enhance intrinsic tendon healing and thus improve the functional outcomes of flexor tendon repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.