ArticleMalaria journal2014
Detection of Plasmodium falciparum and Plasmodium vivax subclinical infection in non-endemic region: implications for blood transfusion and malaria epidemiology.
Article in Malaria journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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23 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Alternative transmission routes in the malaria elimination era: an overview of transfusion-transmitted malaria in the Americas.Malaria journal · 2017Pooled it
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- Complexity of malaria transmission dynamics in the Brazilian Atlantic Forest.Current research in parasitology & vector-borne diseases · 2021Article
- Profiling Humoral Immune Response Against Pre-Erythrocytic and Erythrocytic Antigens of Malaria Parasites Among Neotropical Primates in the Brazilian Atlantic Forest.Frontiers in cellular and infection microbiology · 2021Article
- Attraction of mosquitoes to primate odours and implications for zoonotic Plasmodium transmission.Medical and veterinary entomology · 2020Article
- Effects of anthropogenic landscape changes on the abundance and acrodendrophily of Anopheles (Kerteszia) cruzii, the main vector of malaria parasites in the Atlantic Forest in Brazil.Malaria journal · 2019Article
- A comprehensive analysis of malaria transmission in Brazil.Pathogens and global health · 2019Article
- Strategy to improve malaria surveillance system preventing transfusion-transmitted malaria in blood banks using molecular diagnostic.Malaria journal · 2018Article
- Assessment of asymptomatic Plasmodium spp. infection by detection of parasite DNA in residents of an extra-Amazonian region of Brazil.Malaria journal · 2018Article
- Reassessment of asymptomatic carriers of Plasmodium spp. in an endemic area with a very low incidence of malaria in extra-Amazonian Brazil.Malaria journal · 2017Article
- Molecular Screening for Malaria among Blood Donors in a WHO Claimed Region of Egypt, Fayoum Governorate.Mediterranean journal of hematology and infectious diseases · 2017Article
- Ethical aspects of malaria control and research.Malaria journal · 2015Review
- Spatial and temporal epidemiology of malaria in extra-Amazonian regions of Brazil.Malaria journal · 2015Article
- Plasmodium falciparum in the southeastern Atlantic forest: a challenge to the bromeliad-malaria paradigm?Malaria journal · 2015Article
- Finding connections in the unexpected detection of Plasmodium vivax and Plasmodium falciparum DNA in asymptomatic blood donors: a fact in the Atlantic Forest.Malaria journal · 2014Article
- Unexpected detection of Plasmodium vivax and Plasmodium falciparum DNA in asymptomatic blood donors: fact or artifact?Malaria journal · 2014Article
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10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn Brazil, malaria is endemic in the Amazon River basin and non-endemic in the extra-Amazon region, which includes areas of São Paulo state. In this state, a number of autochthonous cases of malaria occur annually, and the prevalence of subclinical infection is unknown. Asymptomatic infections may remain undetected, maintaining transmission of the pathogen, including by blood transfusion. In these report it has been described subclinical Plasmodium infection in blood donors from a blood transfusion centre in São Paulo, Brazil.
methodsIn this cross-sectional study, representative samples of blood were obtained from 1,108 healthy blood donors at the Fundação Pró-Sangue Hemocentro de São Paulo, the main blood transfusion centre in São Paulo. Malaria exposure was defined by the home region (exposed: forest region; non-exposed: non-forest region). Real-time PCR was used to detect Plasmodium falciparum and Plasmodium vivax. Subclinical malaria cases were geo-referenced.
resultsEighty-four (7.41%) blood donors tested positive for Plasmodium; 57 of these were infected by P. falciparum, 25 by P. vivax, and 2 by both. The prevalence of P. falciparum and P. vivax was 5.14 and 2.26, respectively. The overall prevalence ratio (PR) was 3.23 (95% confidence interval (CI) 2.03, 5.13); P. falciparum PR was 16.11 (95% CI 5.87, 44.21) and P. vivax PR was 0.47 (95% CI 0.2, 1.12). Plasmodium falciparum subclinical malaria infection in the Atlantic Forest domain was present in the mountain regions while P. vivax infection was observed in cities from forest-surrounded areas.
conclusionsThe presence of Plasmodium in healthy blood donors from a region known as non-endemic, which is important in the context of transfusion biosafety, was described. Infected recipients may become asymptomatic carriers and a reservoir for parasites, maintaining their transmission. Furthermore, P. falciparum PR was positively associated with the forest environment, and P. vivax was associated with forest fragmentation.
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