ArticleDiagnostic pathology2014
Radiological and pathological characteristics of giant cell tumor of bone treated with denosumab.
Article in Diagnostic pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Denosumab for Effective Tumor Size Reduction in Patients With Giant Cell Tumors of the Bone: A Systematic Review and Meta-Analysis.Cancer control : journal of the Moffitt Cancer CenterPooled it
- Giant Cell Tumor of Bone: Biology, Pathophysiology, and Histopathology in the Era of H3F3A.Biomedicines · 2026Review
- Skip Lesion in Distal Femur with Recurrent Giant Cell Tumor of the Proximal Femur: A Very Rare Case Managed with Excision, Megaprosthesis Reconstruction, and Bone Cement Curettage.Journal of orthopaedic case reports · 2025Article
- Molecular pathological insights into tumorigenesis and progression of giant cell tumor of bone.Journal of bone oncology · 2025Review
- Case Report: Unresectable pulmonary metastases of a giant cell tumor of bone treated with denosumab: a case report and review of literature.Frontiers in oncology · 2023Article
- A rare case of sphenoid giant cell tumor: Case report & review of imaging features post short-term denosumab treatment.Radiology case reports · 2022Article
- Single-cell RNA sequencing reveals differential expression of EGFL7 and VEGF in giant-cell tumor of bone and osteosarcoma.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Total neurological recovery after surgical decompression and treatment with denosumab of large unresectable spinal giant cell tumour expanding to mediastinum.BMJ case reports · 2022Article
- Review
- Risk factors and oncological outcomes of pulmonary metastasis in patients with giant cell tumor of bone.Journal of clinical orthopaedics and trauma · 2021Article
- Visualization of hidden soft-tissue recurrence of giant cell tumor of bone enabled by preoperative denosumab treatment: a case description.Quantitative imaging in medicine and surgery · 2021Article
- Osteoclasts in Tumor Biology: Metastasis and Epithelial-Mesenchymal-Myeloid Transition.Pathology oncology research : POR · 2021Review
- Giant cell tumor of the bone presenting as swelling of the thumb.Proceedings (Baylor University. Medical Center) · 2020Article
- Radiological findings of denosumab treatment for giant cell tumours of bone.Skeletal radiology · 2020Review
- [Giant cell tumor of bone : Morphology, molecular pathogenesis, and differential diagnosis].Der Pathologe · 2020Review
- Multifactor consciousness level assessment of participants with acquired brain injuries employing human-computer interfaces.Biomedical engineering online · 2020Article
- Evaluation of Local Recurrence in Giant-Cell Tumor of Bone Treated by Neoadjuvant Denosumab.Clinics in orthopedic surgery · 2019Article
- Challenges of denosumab in giant cell tumor of bone, and other giant cell-rich tumors of bone.Current opinion in oncology · 2019Review
- In Vitro Study of the Effects of Denosumab on Giant Cell Tumor of Bone: Comparison with Zoledronic Acid.Pathology oncology research : POR · 2019Article
- Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe a case of giant cell tumor of the proximal tibia with skip bone metastases of the ipsilateral femur in a 20-year-old man. After the neoadjuvant treatment with denosumab, plain radiographs and computed tomography showed marked osteosclerosis and sclerotic rim formation, and 18F-FDG PET/CT showed a decreased standardized uptake value, whereas magnetic resonance imaging showed diffuse enhancement of the tumor, nearly the same findings as those at pretreatment. Pathological findings of the surgical specimen after the denosumab treatment showed benign fibrous histiocytoma-like features with complete disappearance of both mononuclear stromal cells and multinuclear osteoclast-like giant cells. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1090602085125068.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.