ArticleAutophagy2014
A curated census of autophagy-modulating proteins and small molecules: candidate targets for cancer therapy.
Article in Autophagy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
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- Epigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets.Signal transduction and targeted therapy · 2023Review
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- Integrative analysis of shared genetic pathogenesis by autism spectrum disorder and obsessive-compulsive disorder.Bioscience reports · 2019Article
- Cross-disease analysis identified novel common genes for both lung adenocarcinoma and lung squamous cell carcinoma.Oncology letters · 2019Article
- Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth.Autophagy · 2019Article
- A curated target gene pool assisting disease prediction and patient-specific biomarker selection for lung squamous cell carcinoma.Oncology letters · 2018Article
- Knowledge database assisted gene marker selection for chronic lymphocytic leukemia.The Journal of international medical research · 2018Article
- Autophagy in Human Skin Fibroblasts: Impact of Age.International journal of molecular sciences · 2018Article
- Integrative computational evaluation of genetic markers for Alzheimer's disease.Saudi journal of biological sciences · 2018Article
- Integrative computational approach to evaluate risk genes for postmenopausal osteoporosis.IET systems biology · 2018Article
- A Curated Target Gene Pool Assisting Early Disease Prediction and Patient-Specific Treatment for Small Cell Lung Cancer.Journal of computational biology : a journal of computational molecular cell biology · 2018Article
- In vitro anti-influenza virus effect of total flavonoid from Trollius ledebouri Reichb.The Journal of international medical research · 2018Article
- THANATOS: an integrative data resource of proteins and post-translational modifications in the regulation of autophagy.Autophagy · 2018Article
- An Integrative Computational Approach to Evaluate Genetic Markers for Chronic Lymphocytic Leukemia.Journal of computational biology : a journal of computational molecular cell biology · 2017Article
- An Integrative Computational Approach to Evaluate Genetic Markers for Bipolar Disorder.Scientific reports · 2017Article
- Autophagy is required for cell survival under L-asparaginase-induced metabolic stress in acute lymphoblastic leukemia cells.Oncogene · 2017Article
- Targeting of apoptotic pathways by SMAC or BH3 mimetics distinctly sensitizes paclitaxel-resistant triple negative breast cancer cells.Oncotarget · 2017Article
- Diosmetin inhibits cell proliferation and induces apoptosis by regulating autophagy via the mammalian target of rapamycin pathway in hepatocellular carcinoma HepG2 cells.Oncology letters · 2016Article
- Preparation and Preclinical Evaluation of Inhalable Particles Containing Rapamycin and Anti-Tuberculosis Agents for Induction of Autophagy.Pharmaceutical research · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Autophagy, a programmed process in which cell contents are delivered to lysosomes for degradation, appears to have both tumor-suppressive and tumor-promoting functions; both stimulation and inhibition of autophagy have been reported to induce cancer cell death, and particular genes and proteins have been associated both positively and negatively with autophagy. To provide a basis for incisive analysis of those complexities and ambiguities and to guide development of new autophagy-targeted treatments for cancer, we have compiled a comprehensive, curated inventory of autophagy modulators by integrating information from published siRNA screens, multiple pathway analysis algorithms, and extensive, manually curated text-mining of the literature. The resulting inventory includes 739 proteins and 385 chemicals (including drugs, small molecules, and metabolites). Because autophagy is still at an early stage of investigation, we provide extensive analysis of our sources of information and their complex relationships with each other. We conclude with a discussion of novel strategies that could potentially be used to target autophagy for cancer therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.