Evidence map›Paper›PMID 24906070›Full record

ArticleEnvironmental research2014

Exposure to traffic pollution, acute inflammation and autonomic response in a panel of car commuters.

Jeremy A Sarnat, Rachel Golan, Roby Greenwald, Amit U Raysoni, Priya Kewada, Andrea Winquist, Stefanie E Sarnat, W Dana Flanders, Maria C Mirabelli, Jennifer E Zora and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.

  1. Pooled it
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  9. Sub-Clinical Effects of Outdoor Smoke in Affected Communities.International journal of environmental research and public health · 2021
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  13. Acute Effects of Air Pollution and Noise from Road Traffic in a Panel of Young Healthy Adults.International journal of environmental research and public health · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Jeremy A SarnatDepartment of Environmental Health, Rollins School of Public Health-Emory University, Atlanta, GA, USA; Air Pollution and Respiratory Health Branch, Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: jsarnat@sph.emory.edu.
Rachel GolanDepartment of Environmental Health, Rollins School of Public Health-Emory University, Atlanta, GA, USA.
Roby GreenwaldDepartment of Environmental Health, Rollins School of Public Health-Emory University, Atlanta, GA, USA.
Amit U RaysoniDepartment of Environmental Health, Rollins School of Public Health-Emory University, Atlanta, GA, USA.
Priya KewadaDepartment of Environmental Health, Rollins School of Public Health-Emory University, Atlanta, GA, USA.
Andrea WinquistDepartment of Environmental Health, Rollins School of Public Health-Emory University, Atlanta, GA, USA.
Stefanie E SarnatDepartment of Environmental Health, Rollins School of Public Health-Emory University, Atlanta, GA, USA.
W Dana FlandersDepartment of Environmental Health, Rollins School of Public Health-Emory University, Atlanta, GA, USA; Air Pollution and Respiratory Health Branch, Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Maria C MirabelliAir Pollution and Respiratory Health Branch, Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Jennifer E ZoraEmory University School of Medicine, Atlanta, GA, USA.
Michael H BerginDepartment of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
Fuyuen YipAir Pollution and Respiratory Health Branch, Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Emory University · USCenters for Disease Control and Prevention · USNational Center for Environmental Health · USGeorgia Institute of Technology · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

backgroundExposure to traffic pollution has been linked to numerous adverse health endpoints. Despite this, limited data examining traffic exposures during realistic commutes and acute response exists.

objectivesWe conducted the Atlanta Commuters Exposures (ACE-1) Study, an extensive panel-based exposure and health study, to measure chemically-resolved in-vehicle exposures and corresponding changes in acute oxidative stress, lipid peroxidation, pulmonary and systemic inflammation and autonomic response.

methodsWe recruited 42 adults (21 with and 21 without asthma) to conduct two 2-h scripted highway commutes during morning rush hour in the metropolitan Atlanta area. A suite of in-vehicle particulate components were measured in the subjects' private vehicles. Biomarker measurements were conducted before, during, and immediately after the commutes and in 3 hourly intervals after commutes.

resultsAt measurement time points within 3h after the commute, we observed mild to pronounced elevations relative to baseline in exhaled nitric oxide, C-reactive-protein, and exhaled malondialdehyde, indicative of pulmonary and systemic inflammation and oxidative stress initiation, as well as decreases relative to baseline levels in the time-domain heart-rate variability parameters, SDNN and rMSSD, indicative of autonomic dysfunction. We did not observe any detectable changes in lung function measurements (FEV1, FVC), the frequency-domain heart-rate variability parameter or other systemic biomarkers of vascular injury. Water soluble organic carbon was associated with changes in eNO at all post-commute time-points (p<0.0001).

conclusionsOur results point to measureable changes in pulmonary and autonomic biomarkers following a scripted 2-h highway commute.

Indexed as

Acute DiseaseAdultAir PollutionAsthmaAutomobilesAutonomic PathwaysBiomarkersEnvironmental ExposureFemaleHumansInflammationInflammation MediatorsMaleMiddle AgedParticulate MatterVehicle EmissionsBiomarkersInflammation MediatorsParticulate MatterVehicle EmissionsAsthmaCar commuteExhaled nitric oxideHeart rate variability

Identifiers

PMID24906070
PMCPMC4807398
OpenAlexW1970241292

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.