ArticleEnvironmental health perspectives2014
Lead exposure, B vitamins, and plasma homocysteine in men 55 years of age and older: the VA normative aging study.
Article in Environmental health perspectives, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Serum Homocysteine Concentration Is Significantly Associated with Inflammatory/Immune Factors.PloS one · 2015Trial
- Sulfur-Containing Amino Acid Homeostasis in the Central Nervous System: From Physiology Regulation to Metal-Induced Neurotoxicity.Metabolites · 2026Review
- Article
- Detrimental impact of solar and geomagnetic activity on plasma B-complex vitamins in the VA normative aging study cohort.Scientific reports · 2024Article
- Blood Homocysteine Levels Mediate the Association Between Blood Lead Levels and Cardiovascular Mortality.Cardiovascular toxicology · 2024Article
- Epigenome-wide DNA methylation in leukocytes and toenail metals: The normative aging study.Environmental research · 2023Article
- Association and mediation analyses among multiple metals exposure, plasma folate, and community-based impaired estimated glomerular filtration rate in central Taiwan.Environmental health : a global access science source · 2022Article
- Associations of Plasma Folate and Vitamin B6 With Blood DNA Methylation Age: An Analysis of One-Carbon Metabolites in the VA Normative Aging Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Modification of vitamin B6 on the associations of blood lead levels and cardiovascular diseases in the US adults.BMJ nutrition, prevention & health · 2020Article
- Metabolomic signatures of lead exposure in the VA Normative Aging Study.Environmental research · 2020Article
- Nonlinear association between blood lead and hyperhomocysteinemia among adults in the United States.Scientific reports · 2020Article
- Exposure to Toxic Heavy Metals Can Influence Homocysteine Metabolism?Antioxidants (Basel, Switzerland) · 2019Review
- Dietary patterns, bone lead and incident coronary heart disease among middle-aged to elderly men.Environmental research · 2019Article
- Blood lead, cadmium and mercury in relation to homocysteine and C-reactive protein in women of reproductive age: a panel study.Environmental health : a global access science source · 2017Article
Corrections and comments
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Authors and funding
10 authors at 9 institutions in 3 countries.
Funding
Abstract
backgroundLead (Pb) exposure may influence the plasma concentration of homocysteine, a one-carbon metabolite associated with cardiovascular and neurodegenerative diseases. Little is known about the associations between Pb and homocysteine over time, or the potential influence of dietary factors.
objectivesWe examined the longitudinal association of recent and cumulative Pb exposure with homocysteine concentrations and the potential modifying effect of dietary nutrients involved in one-carbon metabolism.
methodsIn a subcohort of the Veterans Affairs (VA) Normative Aging Study (1,056 men with 2,301 total observations between 1993 and 2011), we used mixed-effects models to estimate differences in repeated measures of total plasma homocysteine across concentrations of Pb in blood and tibia bone, assessing recent and cumulative Pb exposure, respectively. We also assessed effect modification by dietary intake and plasma concentrations of folate, vitamin B6, and vitamin B12.
resultsAn interquartile range (IQR) increment in blood Pb (3 μg/dL) was associated with a 6.3% higher homocysteine concentration (95% CI: 4.8, 7.8%). An IQR increment in tibia bone Pb (14 μg/g) was associated with a 3.7% higher homocysteine (95% CI: 1.6, 5.6%), which was attenuated to 1.5% (95% CI: -0.5, 3.6%) after adjusting for blood Pb. For comparison, a 5-year increase in time from baseline was associated with a 5.7% increase in homocysteine (95% CI: 4.3, 7.1%). The association between blood Pb and homocysteine was significantly stronger among participants with estimated dietary intakes of vitamin B6 and folate below (vs. above) the study population medians, which were similar to the U.S. recommended dietary allowance intakes.
conclusionsPb exposure was positively associated with plasma homocysteine concentration. This association was stronger among men with below-median dietary intakes of vitamins B6 and folate. These findings suggest that increasing intake of folate and B6 might reduce Pb-associated increases in homocysteine, a risk factor for cardiovascular disease and neurodegeneration.
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