ArticlePloS one2014
Transfer entropy reconstruction and labeling of neuronal connections from simulated calcium imaging.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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50 citing papers in PubMed.
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- Inferring effective networks of spiking neurons using a continuous-time estimator of transfer entropy.PLoS computational biology · 2025Article
- Spontaneous Dynamics Predict the Effects of Targeted Intervention in Hippocampal Neuronal Cultures.bioRxiv : the preprint server for biology · 2025Article
- Neural network embedding of functional microconnectome.Network neuroscience (Cambridge, Mass.) · 2025Article
- Inferring structure of cortical neuronal networks from activity data: A statistical physics approach.PNAS nexus · 2025Article
- Maximum likelihood estimation of spatially dependent interactions in large populations of cortical neurons.Frontiers in computational neuroscience · 2025Article
- The precision principle: driving biological self-organization.Frontiers in network physiology · 2025Article
- Ensemble learning and ground-truth validation of synaptic connectivity inferred from spike trains.PLoS computational biology · 2024Article
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- Response inhibition in premotor cortex corresponds to a complex reshuffle of the mesoscopic information network.Network neuroscience (Cambridge, Mass.) · 2024Article
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- 344Laser bioprinting of human iPSC-derived neural stem cells and neurons: Effect on cell survival, multipotency, differentiation, and neuronal activity.International journal of bioprinting · 2023Article
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- Early lock-in of structured and specialised information flows during neural development.eLife · 2022Article
- Analysis of co-isogenic prion protein deficient mice reveals behavioral deficits, learning impairment, and enhanced hippocampal excitability.BMC biology · 2022Article
- Disparate insults relevant to schizophrenia converge on impaired spike synchrony and weaker synaptic interactions in prefrontal local circuits.Current biology : CB · 2022Article
- Involvement of Mechanical Cues in the Migration of Cajal-Retzius Cells in the Marginal Zone During Neocortical Development.Frontiers in cell and developmental biology · 2022Article
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5 authors.
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Abstract
Neuronal dynamics are fundamentally constrained by the underlying structural network architecture, yet much of the details of this synaptic connectivity are still unknown even in neuronal cultures in vitro. Here we extend a previous approach based on information theory, the Generalized Transfer Entropy, to the reconstruction of connectivity of simulated neuronal networks of both excitatory and inhibitory neurons. We show that, due to the model-free nature of the developed measure, both kinds of connections can be reliably inferred if the average firing rate between synchronous burst events exceeds a small minimum frequency. Furthermore, we suggest, based on systematic simulations, that even lower spontaneous inter-burst rates could be raised to meet the requirements of our reconstruction algorithm by applying a weak spatially homogeneous stimulation to the entire network. By combining multiple recordings of the same in silico network before and after pharmacologically blocking inhibitory synaptic transmission, we show then how it becomes possible to infer with high confidence the excitatory or inhibitory nature of each individual neuron.
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