ArticleMolecules (Basel, Switzerland)2014
Fabrication of implantable, enzyme-immobilized glutamate sensors for the monitoring of glutamate concentration changes in vitro and in vivo.
Article in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Creation of an Engineered Oxygen-Insensitive L-Glutamate Oxidase for the Application of Electrochemical L-Glutamate Sensors.International journal of molecular sciences · 2026Article
- Enzyme-Mediated Organic Neurohybrid Synapses.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- Surface-modified CMOS biosensors.Frontiers in bioengineering and biotechnology · 2024Review
- Electrochemical study of the effect of radiofrequency on glutamate oxidase activity using a glutamate oxidase-based biosensor.Heliyon · 2023Article
- Cultivating Multidisciplinarity: Manufacturing and Sensing Challenges in Cultured Meat Production.Biology · 2021Review
- Frontiers in Electrochemical Sensors for Neurotransmitter Detection: Towards Measuring Neurotransmitters as Chemical Diagnostics for Brain Disorders.Analytical methods : advancing methods and applications · 2019Article
- A Detailed Model of Electroenzymatic Glutamate Biosensors To Aid in Sensor Optimization and in Applications in Vivo.ACS chemical neuroscience · 2018Article
- A Novel Microbiosensor Microarray for ContinuousFrontiers in neuroscience · 2018Article
- Special Issue: Enzyme Immobilization 2016.Molecules (Basel, Switzerland) · 2017Article
- Characterization of Biosensors Based on Recombinant Glutamate Oxidase: Comparison of Crosslinking Agents in Terms of Enzyme Loading and Efficiency Parameters.Sensors (Basel, Switzerland) · 2016Article
- Wireless Power Transfer for Autonomous Wearable Neurotransmitter Sensors.Sensors (Basel, Switzerland) · 2015Article
- Label Free Detection of L-Glutamate Using Microfluidic Based Thermal Biosensor.Bioengineering (Basel, Switzerland) · 2015Article
- Editorial: Special issue--Enzyme immobilization.Molecules (Basel, Switzerland) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutamate sensors based on the immobilization of glutamate oxidase (GlutOx) were prepared by adsorption on electrodeposited chitosan (Method 1) and by crosslinking with glutaraldehyde (Method 2) on micromachined platinum microelectrodes. It was observed that glutamate sensors prepared by Method 1 have faster response time (<2 s) and lower detection limit (2.5±1.1 μM) compared to that prepared by Method 2 (response time: <5 sec and detection limit: 6.5±1.7 μM); glutamate sensors prepared by Method 2 have a larger linear detection range (20-352 μM) and higher sensitivity (86.8±8.8 nA·μM-1·cm-2, N=12) compared to those prepared by Method 1 (linear detection range: 20-217 μM and sensitivity: 34.9±4.8 nA·μM-1·cm-2, N=8). The applicability of the glutamate sensors in vivo was also demonstrated. The glutamate sensors were implanted into the rat brain to monitor the stress-induced extracellular glutamate release in the hypothalamus of the awake, freely moving rat.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.