ArticlePloS one2014
Exposure to Beta-(1,3)-D-glucan in house dust at age 7-10 is associated with airway hyperresponsiveness and atopic asthma by age 11-14.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Childhood asthma and mould in homes-A meta-analysis.Wiener klinische Wochenschrift · 2025Pooled it
- The relationship of domestic pet ownership with the risk of childhood asthma: A systematic review and meta-analysis.Frontiers in pediatrics · 2022Pooled it
- Fungal diversity in homes and asthma morbidity among school-age children in New York City.Environmental research · 2023Article
- Bioaerosol dispersion and environmental risk simulation: Method and a case study for a biopharmaceutical plant of Gansu province, China.The Science of the total environment · 2023Article
- Innovative compounds to reduce β-D-glucans, endotoxin, and allergens newly discovered on smartphones.The journal of allergy and clinical immunology. Global · 2023Article
- The Effects and Pathogenesis of PM2.5 and Its Components on Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2023Review
- Indoor microbiome and allergic diseases: From theoretical advances to prevention strategies.Eco-Environment & Health · 2022Review
- Housing conditions and respiratory morbidity in Indigenous children in remote communities in Northwestern Ontario, Canada.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2022Article
- Effects of Air Pollutants on Airway Diseases.International journal of environmental research and public health · 2021Review
- Indoor Airborne Microbial Concentration and Dry Eye.American journal of ophthalmology · 2021Observational
- Vaping and e-cigarette use. Mysterious lung manifestations and an epidemic.Current opinion in immunology · 2020Review
- Microbial Toxins in E-Liquid: A Potential New Vaping-Related Exposure to Explore.Environmental health perspectives · 2019Article
- Endotoxin andEnvironmental health perspectives · 2019Article
- Airborne bioaerosols and their impact on human health.Journal of environmental sciences (China) · 2018Review
- Dysregulated invertebrate tropomyosin-dectin-1 interaction confers susceptibility to allergic diseases.Science immunology · 2018Article
- Associations between sensitization to perennial/seasonal allergens and childhood asthma.Allergologie select · 2018Article
- Environmental determinants of allergy and asthma in early life.The Journal of allergy and clinical immunology · 2017Review
- Fungal Exposure and Asthma: IgE and Non-IgE-Mediated Mechanisms.Current allergy and asthma reports · 2016Review
- Characterization of the bacterial and fungal microbiome in indoor dust and outdoor air samples: a pilot study.Environmental science. Processes & impacts · 2016Article
- Industrial hygiene, occupational safety and respiratory symptoms in the Pakistani cotton industry.BMJ open · 2015Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundMould exposure has been linked to childhood asthma and bronchial hyper-responsiveness. Few studies have assessed beta-(1,3)-d-glucan (beta-glucan), a significant fungal cell wall constituent, in relation to asthma in adolescence.
objectiveTo determine whether house dust-derived beta-glucan exposure at age 7-10 is associated with the development and persistence of atopic and non-atopic asthma, and bronchial hyper-responsiveness (BHR) by age 11-14.
methodsDust samples were collected from the 1995 Study of Asthma, Genes, and Environment (SAGE) birth cohort. This cohort was derived from Manitoba provincial healthcare administrative records of children high and low risk for asthma. Samples were collected from the homes of 422 children at age 7-10 and analyzed using beta-glucan and endotoxin-specific Limulus Amoebocyte Lysate assays. Asthma, atopy, and BHR status of each child were also assessed at ages 7-10 and 11-14.
resultsAt age 7-10, beta-glucan dust levels in the home were associated with persistent atopic asthma at age 11-14 (OR 1.79 for each unit increase in levels, 95% CI 1.14-2.81), independent of endotoxin exposure, and Alternaria or Cladosporium sensitization. The likelihood of BHR almost doubled with unit increases in dust beta-glucan in asthmatic children. In children without asthma, exposure to high beta-glucan levels at age 7-10 also elevated risk for BHR in adolescence (OR 1.74, 95% CI 1.05-2.89). New-onset atopic asthma was twice more likely following high beta-glucan exposure in children without asthma but the association did not reach statistical significance. No associations were evident with concurrent asthma phenotype at age 7-10 or non-atopic asthma at age 11-14.
conclusionThese findings implicate home beta-glucan exposure at school-age as a risk factor for persistent atopic asthma and new-onset BHR. The higher prevalence of BHR in urban adolescents may be propagated by this home exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.