ArticlePloS one2014
An 18-gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- LINC00472 expression is regulated by promoter methylation and associated with disease-free survival in patients with grade 2 breast cancer.Breast cancer research and treatment · 2015Pooled it
- Improved survival analysis by learning shared genomic information from pan-cancer data.Bioinformatics (Oxford, England) · 2020Article
- A key genomic subtype associated with lymphovascular invasion in invasive breast cancer.British journal of cancer · 2019Article
- Identification of key pathways and genes in response to trastuzumab treatment in breast cancer using bioinformatics analysis.Oncotarget · 2018Article
- Deficiency of mitochondrial modulator MCJ promotes chemoresistance in breast cancer.JCI insight · 2016Article
- Tumor necrosis is an important hallmark of aggressive endometrial cancer and associates with hypoxia, angiogenesis and inflammation responses.Oncotarget · 2015Article
- Article
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Authors and funding
4 authors.
Funding
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Abstract
aimsVascular invasion by tumor cells is known to be important for cancer progression. By microarray and qPCR analyses, we earlier identified an 18-gene signature associated with vascular involvement in endometrial cancer. Here, we explored the significance of this vascular invasion signature in multiple series of breast cancer patients. METHODS AND
resultsThe study includes 11 open access gene expression data sets which collectively provide information on 2423 breast cancer patients. The 18-gene signature showed consistent associations with aggressive features of breast cancer, like high tumor grade, hormone receptor negativity, HER2 positivity, a basal-like phenotype, reduced patient survival, and response to neoadjuvant chemotherapy. Also, the vascular invasion signature was associated with several other gene expression profiles related to vascular biology and tumor progression, including the Oncotype DX breast cancer recurrence signature.
conclusionsThe 18-gene vascular invasion signature showed strong and consistent associations with aggressive features of breast cancer and reduced survival.
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