Evidence map›Paper›PMID 24905161›Full record

ArticleCell stem cell2014

Saying no to drugs: fasting protects hematopoietic stem cells from chemotherapy and aging.

Christopher Hine, James R Mitchell

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stem cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Christopher HineDepartment of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
James R MitchellDepartment of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA. Electronic address: jmitchel@hsph.harvard.edu.

Funding

Mechanisms of dietary control of the transsulfuration pathway and increased endogenous hydrogen sulfide productionR01DK090629 · NIDDK · HARVARD SCHOOL OF PUBLIC HEALTH · PI MITCHELL, SARAH JAYNE · 2011 to 2019
$3.0M
Protection against renal ischemic injury by short term dietary restrictionR01AG036712 · NIA · HARVARD SCHOOL OF PUBLIC HEALTH · PI MITCHELL, JAMES R. · 2010 to 2014
$1.6M
NIA NIH HHS R01 AG036712NIDDK NIH HHS R01 DK090629
6 · The paper itself

Abstract

Aging and chemotherapeutics damage hematopoietic stem cells (HSCs), leading to dysregulation of asymmetric division and subsequent immunosuppression and blood-related diseases. In this issue, Cheng et al. (2014) use prolonged fasting as a medical intervention to decrease IGF-1/PKA signaling and protect HSCs against chemotherapeutic toxicity and promote rejuvenation.

Indexed as

Immunosuppression TherapyRegenerationAnimalsCyclic AMP-Dependent Protein KinasesFastingHematopoietic Stem CellsInsulin-Like Growth Factor ICyclic AMP-Dependent Protein Kinasesinsulin-like growth factor-1, mouseInsulin-Like Growth Factor I

Identifiers

PMID24905161
PMCPMC4278638

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.