ArticlePloS one2014
CLOCK 3111 T/C SNP interacts with emotional eating behavior for weight-loss in a Mediterranean population.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02829619 (Meal Timing, Genetics and Weight Loss in a Mediterranean Population), which is not on this map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Meal Timing, Genetics and Weight Loss in a Mediterranean Population
Who cites it
23 citing papers in PubMed.
- Key Determinants of Weight Loss Trajectory Across Different Periods of a Behavioral Weight Loss Intervention.Obesity (Silver Spring, Md.) · 2026Trial
- Article
- Reduction of High Emotional Eating via Increased Physical Activity: Assessing a Path Informed by Multiple Behavioral Theories Within Community-Based Obesity Interventions.Journal of prevention (2022) · 2025Article
- Mediterranean diet and obesity polygenic risk interaction on adiposity in European children: The IDEFICS/I.Family Study.Pediatric obesity · 2025Article
- Emotional Eating and Mental Health Among Lebanese University Students During COVID-19 Outbreak.Journal of nutrition and metabolism · 2025Article
- Genes Involved in Susceptibility to Obesity and Emotional Eating Behavior in a Romanian Population.Nutrients · 2024Article
- Emotional eating and mental health of nurses working in Lebanese hospitals during the double crisis.Journal of nutritional science · 2024Article
- CETP and APOA2 polymorphisms are associated with weight loss and healthy eating behavior changes in response to digital lifestyle modifications.Scientific reports · 2023Article
- Chrono-Nutrition: Circadian Rhythm and Personalized Nutrition.International journal of molecular sciences · 2023Review
- Emotional and intuitive eating: an emerging approach to eating behaviours related to obesity.Journal of nutritional science · 2023Article
- Olive Oil in the Mediterranean Diet and Its Biochemical and Molecular Effects on Cardiovascular Health through an Analysis of Genetics and Epigenetics.International journal of molecular sciences · 2022Review
- Review
- Association and interaction of the MC4R rs17782313 polymorphism with plasma ghrelin, GLP-1, cortisol, food intake and eating behaviors in overweight/obese Iranian adults.BMC endocrine disorders · 2022Article
- Emotional Eating and Dietary Patterns: Reflecting Food Choices in People with and without Abdominal Obesity.Nutrients · 2022Article
- Adherence to Mediterranean Diet, Alcohol Consumption and Emotional Eating in Spanish University Students.Nutrients · 2021Observational
- Daily Rhythm of Fractal Cardiac Dynamics Links to Weight Loss Resistance: Interaction withNutrients · 2021Article
- Mindfulness-based emotional eating awareness training: taking the emotional out of eating.Eating and weight disorders : EWD · 2020Article
- Sex modifies the association between the CLOCK variant rs1801260 and BMI in school-age children.PloS one · 2020Article
- Metabolic and Vascular Effect of the Mediterranean Diet.International journal of molecular sciences · 2019Review
- Evening chronotype associates with obesity in severely obese subjects: interaction with CLOCK 3111T/C.International journal of obesity (2005) · 2016Observational
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveThe goals of this research was (1) to analyze the role of emotional eating behavior on weight-loss progression during a 30-week weight-loss program in 1,272 individuals from a large Mediterranean population and (2) to test for interaction between CLOCK 3111 T/C SNP and emotional eating behavior on the effectiveness of the weight-loss program. DESIGN AND
methodsA total of 1,272 overweight and obese participants (BMI: 31±5 kg/m2), aged 20 to 65 years, attending outpatient weight-loss clinics were recruited for this analysis. Emotional eating behavior was assessed by the Emotional Eating Questionnaire (EEQ), a questionnaire validated for overweight and obese Spanish subjects. Anthropometric measures, dietary intake and weight-loss progression were assessed and analyzed throughout the 30-week program. Multivariate analysis and linear regression models were performed to test for gene-environment interaction.
resultsWeight-loss progression during the 30-week program differed significantly according to the degree of emotional eating behavior. Participants classified as 'very emotional eaters' experienced more irregular (P = 0.007) weight-loss, with a lower rate of weight decline (-0.002 vs. -0.003, P<0.05) in comparison with less emotional eaters. The percentage of weight-loss was also significantly higher in 'non-emotional eaters' (P = 0.009). Additionally, we identified a significant gene-environment interaction associated with weight-loss at the CLOCK 3111 T/C locus (P = 0.017). By dichotomizing the emotional eating behavior score, linear regression analysis indicated that minor C allele carriers with a high emotional score (> = 11), lost significantly less weight than those C carriers with a low emotional score (<11) (P = 0.005).
conclusionsEmotional eating behavior associates with weight-loss pattern, progression and total weight-loss. Additionally, CLOCK 3111 T/C SNP interacts with emotional eating behavior to modulate total weight loss. These results suggest that the assessment of this locus and emotional eating behavior could improve the development of effective, long-tern weight-management interventions.
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