ArticleAnnals of pediatric endocrinology & metabolism2013
Estrogen receptor α polymorphism in boys with constitutional delay of growth and puberty.
Article in Annals of pediatric endocrinology & metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- Estrogen Receptor 1 Gene Polymorphism and its Association with Idiopathic Short Stature in a North Indian PopulationJournal of clinical research in pediatric endocrinology · 2024Article
- Stability of proposed biomarkers of prenatal androgen exposure over the menstrual cycle.Journal of developmental origins of health and disease · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThere were a lot of reports regarding associations of polymorphisms in the estrogen receptor α (ESR1). with many disorders. But, those with constitutional delay of growth and puberty (CDGP) are not known. Our aim is to find out any association between CDGP and ESR1.
methodsIn a total of 27 subjects, we compared 7 CDGP patients with 20 healthy controls with their heights and sexual maturity rates were within normal range. We selected three single nucleotide polymorphisms from intron 1 of ESR1 (rs3778609, rs12665044, and rs827421) as candidates, respectively.
resultsIn genotype analyses, the frequency of G/G genotype at rs827421 in intron 1 of ESR1 was increased in CDGP boys (P=0.03).
conclusionThe genetic variation of ESR1 can be a contributing factor of tempo of growth and puberty.
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