ReviewF1000prime reports2014
Learning from myocarditis: mimicry, chaos and black holes.
Review in F1000prime reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- From Bench to Bedside: Translational Approaches to Cardiotoxicity in Breast Cancer, Lung Cancer, and Lymphoma Therapies.Cancers · 2025Review
- Infectious factors in myocarditis: a comprehensive review of common and rare pathogens.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2024Review
- Review
- The Anti-Inflammatory and Immunomodulatory Activities of Natural Products to Control Autoimmune Inflammation.International journal of molecular sciences · 2022Review
- Circulating c-Met-Expressing Memory T Cells Define Cardiac Autoimmunity.Circulation · 2022Article
- Implication of microRNA as a potential biomarker of myocarditis.Clinical and experimental pediatrics · 2022Article
- Fulminant myocarditis in adults: a narrative review.Journal of geriatric cardiology : JGC · 2022Article
- Early application of extracorporeal membrane oxygenation for myocarditis with shock: a case report.The Journal of international medical research · 2021Article
- Update on acute myocarditis.Trends in cardiovascular medicine · 2021Review
- Evidence of SARS-CoV-2-Specific T-Cell-Mediated Myocarditis in a MIS-A Case.Frontiers in immunology · 2021Article
- Circulating Exosomes Control CD4Molecular therapy : the journal of the American Society of Gene Therapy · 2020Article
- Management of Acute Myocarditis and Chronic Inflammatory Cardiomyopathy: An Expert Consensus Document.Circulation. Heart failure · 2020Review
- From Anti-EBV Immune Responses to the EBV Diseasome via Cross-reactivity.Global medical genetics · 2020Article
- Viewing Autoimmune Pathogenesis from the Perspective of Antigen Processing and Determinant Hierarchy.Critical reviews in immunology · 2020Article
- Second waves, social distancing, and the spread of COVID-19 across the USA.Wellcome open research · 2020Article
- Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis.The Journal of experimental medicine · 2019Article
- Acute and Fulminant Myocarditis: a Pragmatic Clinical Approach to Diagnosis and Treatment.Current cardiology reports · 2018Review
- Roles of Host Immunity in Viral Myocarditis and Dilated Cardiomyopathy.Journal of immunology research · 2018Review
- Myocarditis Elicits Dendritic Cell and Monocyte Infiltration in the Heart and Self-Antigen Presentation by Conventional Type 2 Dendritic Cells.Frontiers in immunology · 2018Article
- T-cell immunity in myocardial inflammation: pathogenic role and therapeutic manipulation.British journal of pharmacology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Autoimmune myocarditis and its sequel, dilated cardiomyopathy, are major causes of heart failure, especially in children and young adults. We have developed animal models to investigate their pathogenesis by infecting genetically susceptible mice with coxsackievirus B3 or by immunizing them with cardiac myosin or its immunodominant peptide. A number of valuable lessons have emerged from our study of this paradigm of an infection-induced autoimmune disease. We understand more clearly how natural autoimmunity, as an important component of normal physiology, must be recalibrated regularly due to changes caused by infection or other internal and external stimuli. A new normal homeostatic platform will be established based on its evolutionary fitness. A loss of homeostasis with out-of-control normal autoimmunity leads to autoimmune disease. It is signified early on by a spread of an adaptive autoimmune response to novel epitopes and neighboring antigens. The progression from infection to normal, well-balanced autoimmunity to autoimmune disease and on to irreversible damage is a complex, step-wise process. Yet, chaos theory provides hope that the pattern is potentially predictable. Infection-induced autoimmune disease represents a sequence of events heading for a train wreck at the end of the line. Our aim in autoimmune disease research must be to stop the train before this happens.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.