Evidence map›Paper›PMID 24904686›Full record

ArticleInfectious agents and cancer2014

Prognosis and delay of diagnosis among Kaposi's sarcoma patients in Uganda: a cross-sectional study.

Christopher De Boer, Nixon Niyonzima, Jackson Orem, John Bartlett, S Yousuf Zafar

Abstract read
In one paragraph

Article in Infectious agents and cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  12. Kaposi sarcoma.Nature reviews. Disease primers · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Christopher De BoerDuke Global Health Institute, Duke University, 310 Trent Drive, Durham, NC 27710, USA ; University of Iowa Carver College of Medicine, 375 Newton Road, Iowa City, IA 52242, USA.
Nixon NiyonzimaDuke Global Health Institute, Duke University, 310 Trent Drive, Durham, NC 27710, USA ; Uganda Cancer Institute, Upper Mulago Hill Rd, Kampala, Uganda ; College of Health Sciences, Makerere University, Kampala, Uganda ; University of Washington, Seattle, WA, USA ; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Jackson OremUganda Cancer Institute, Upper Mulago Hill Rd, Kampala, Uganda ; College of Health Sciences, Makerere University, Kampala, Uganda ; Uganda Program on Cancer and Infectious Disease, Kampala, Uganda.
John BartlettDuke Global Health Institute, Duke University, 310 Trent Drive, Durham, NC 27710, USA ; Duke University Medical Center, Duke University, 10 Bryan Searle Drive, Durham, NC 27710, USA.
S Yousuf ZafarDuke Global Health Institute, Duke University, 310 Trent Drive, Durham, NC 27710, USA ; Duke University Medical Center, Duke University, 10 Bryan Searle Drive, Durham, NC 27710, USA ; Duke Cancer Institute, Durham, NC, USA.

Funding

Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5M
NIAID NIH HHS P30 AI064518
6 · The paper itself

Abstract

backgroundIn low- and middle-income countries, the association between delay to treatment and prognosis for Kaposi's sarcoma (KS) patients is yet to be studied.

methodsThis is a prospective study of HIV-infected adults with histologically-confirmed KS treated at the Uganda Cancer Institute (UCI). Standardized interviews were conducted in English or Luganda. Medical records were abstracted for KS stage at admission to UCI. Multivariable logistic regression assessed relationships between diagnostic delay and stage at diagnosis.

resultsOf 161 patients (90% response rate), 69% were men, and the mean age was 34.0 years (SD 7.7). 26% had been seen in an HIV clinic within 3 months, 72% were on antiretroviral therapy, and 26% had visited a traditional healer prior to diagnosis. 45% delayed seeking care at UCI for ≥3 months from symptom onset. Among those who delayed, 36% waited 6 months, and 25% waited 12 months. Common reasons for delay were lack of pain (48%), no money (32%), and distance to UCI (8%). In adjusted analysis patients who experienced diagnostic delay were more likely than those who did not delay to have poor-risk KS stage (OR 3.41, p = 0.002, 95% CI: 1.46-7.45). In adjusted analyses visiting a traditional healer was the only variable associated with greater likelihood of delay (OR 2.69, p = 0.020, 95% CI: 1.17-6.17).

conclusionsDiagnostic delay was associated with poor-risk stage at diagnosis, and visiting a traditional healer was associated with higher odds of delay. The relationship between traditional and Western medicine presents a critical intervention point to improve KS-related outcomes in Uganda.

Indexed as

CancerDelayed diagnosisHIVKaposi’s sarcomaUganda

Identifiers

PMID24904686
PMCPMC4045870

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.