ArticleFrontiers in neurology2014
Cytomorphometric Changes in Hippocampal CA1 Neurons Exposed to Simulated Microgravity Using Rats as Model.
Article in Frontiers in neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Sensory Deprivation and the Brain: Neurobiological Mechanisms, Psychological Effects, and Clinical Implications.Brain sciences · 2026Review
- Spaceflight and Ground-Based Microgravity Simulation Impact on Cognition and Brain Plasticity.International journal of molecular sciences · 2025Review
- [Potential biological mechanisms underlying spaceflight-induced depression symptoms in astronauts].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Review
- Formaldehyde initiates memory and motor impairments under weightlessness condition.NPJ microgravity · 2024Review
- Physical exercise restores adult neurogenesis deficits induced by simulated microgravity.NPJ microgravity · 2024Article
- Long-term spaceflight composite stress induces depression and cognitive impairment in astronauts-insights from neuroplasticity.Translational psychiatry · 2023Review
- Role ofAnnals of neurosciences · 2023Article
- Time-course adaptive changes in hippocampal transcriptome and synaptic function induced by simulated microgravity associated with cognition.Frontiers in cellular neuroscience · 2023Article
- Artificial gravity partially protects space-induced neurological deficits in Drosophila melanogaster.Cell reports · 2022Article
- Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation.NPJ microgravity · 2021Article
- Dammarane Sapogenins Improving Simulated Weightlessness-Induced Depressive-Like Behaviors and Cognitive Dysfunction in Rats.Frontiers in psychiatry · 2021Article
- Neuromorphometric changes associated with photostimulated migratory phenotype in the Palaearctic-Indian male redheaded bunting.Experimental brain research · 2020Article
- Impairment of synaptic plasticity and novel object recognition in the hypergravity-exposed rats.Scientific reports · 2020Article
- Involvement of Cholinergic Dysfunction and Oxidative Damage in the Effects of Simulated Weightlessness on Learning and Memory in Rats.BioMed research international · 2018Article
- Adaptive Changes in the Vestibular System of Land Snail to a 30-Day Spaceflight and Readaptation on Return to Earth.Frontiers in cellular neuroscience · 2017Article
- Hypergravity stimulation enhances PC12 neuron-like cell differentiation.BioMed research international · 2015Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Microgravity and sleep loss lead to cognitive and learning deficits. These behavioral alterations are likely to be associated with cytomorphological changes and loss of neurons. To understand the phenomenon, we exposed rats (225-275 g) to 14 days simulated microgravity (SMg) and compared its effects on CA1 hippocampal neuronal plasticity, with that of normal cage control rats. We observed that the mean area, perimeter, synaptic cleft, and length of active zone of CA1 hippocampal neurons significantly decreased while dendritic arborization and number of spines significantly increased in SMg group as compared with controls. The mean thickness of the postsynaptic density and total dendritic length remained unaltered. The changes may be a compensatory effect induced by exposure to microgravity; however, the effects may be transient or permanent, which need further study. These findings may be useful for designing effective prevention for those, including the astronauts, exposed to microgravity. Further, subject to confirmation, we propose that SMg exposure might be useful for recovery of stroke patients.
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