Evidence map›Paper›PMID 24904420›Full record

ReviewFrontiers in pharmacology2014

Epidemiological associations between iron and cardiovascular disease and diabetes.

Debargha Basuli, Richard G Stevens, Frank M Torti, Suzy V Torti

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it, 120 citations in OpenAlex.

  1. Pooled it
  2. Research progress of ferroptosis in obesity and its complications.Journal of physiology and biochemistry · 2026
    Review
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  4. Article
  5. Review
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  8. Review
  9. Article
  10. Article
  11. Review
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  13. The role of regulated necrosis in diabetes and its complications.Journal of molecular medicine (Berlin, Germany) · 2024
    Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Debargha BasuliMolecular Biology and Biophysicis, University of Connecticut Health Center, Farmington CT, USA.
Richard G StevensDivision of Epidemiology and Biostatistics, Department of Community Medicine and Health Care, University of Connecticut Health Center, Farmington CT, USA.
Frank M TortiInternal Medicine, University of Connecticut Health Center, Farmington CT, USA.
Suzy V TortiMolecular Biology and Biophysicis, University of Connecticut Health Center, Farmington CT, USA.
UConn Health · US

Funding

Ferroportin and Iron HomeostasisR01CA171101 · NCI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI TORTI, FRANK M. · 2012 to 2016
$1.7M
NCI NIH HHS R01 CA171101
6 · The paper itself

Abstract

Disruptions in iron homeostasis are linked to a broad spectrum of chronic conditions including cardiovascular, malignant, metabolic, and neurodegenerative disease. Evidence supporting this contention derives from a variety of analytical approaches, ranging from molecular to population-based studies. This review focuses on key epidemiological studies that assess the relationship between body iron status and chronic diseases, with particular emphasis on atherosclerosis ,metabolic syndrome and diabetes. Multiple surrogates have been used to measure body iron status, including serum ferritin, transferrin saturation, serum iron, and dietary iron intake. The lack of a uniform and standardized means of assessing body iron status has limited the precision of epidemiological associations. Intervention studies using depletion of iron to alter risk have been conducted. Genetic and molecular techniques have helped to explicate the biochemistry of iron metabolism at the molecular level. Plausible explanations for how iron contributes to the pathogenesis of these chronic diseases are beginning to be elucidated. Most evidence supports the hypothesis that excess iron contributes to chronic disease by fostering excess production of free radicals. Overall, epidemiological studies, reinforced by basic science experiments, provide a strong line of evidence supporting the association between iron and elevated risk of cardiovascular disease and diabetes. In this narrative review we attempt to condense the information from existing literature on this topic.

Indexed as

cardiovascular diseasediabetes mellitusepidemiologic studiesironmetabolic syndrome

Identifiers

PMID24904420
PMCPMC4033158
OpenAlexW2115120153

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.