ReviewFrontiers in behavioral neuroscience2014
Getting a grip on problem gambling: what can neuroscience tell us?
Review in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Non-invasive Brain Stimulation for Gambling Disorder: A Systematic Review.Frontiers in neuroscience · 2020Pooled it
- Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead.Neuroscience and biobehavioral reviews · 2019Pooled it
- Trial
- Distinguishing Persistent Versus Episodic Clusters of At-Risk Respondents on the Problem Gambling Severity Index.Journal of gambling studies · 2025Article
- Efficacy of Continuous Theta Burst Stimulation to the Pre-supplementary Motor Area in Gambling Disorder: a Randomized Double-Blind Controlled Trial.International journal of mental health and addiction · 2025Article
- For Better and For Worse: Frequent Gamblers Use Dual Counterfactuals to Justify Continued Gambling.Journal of gambling studies · 2024Article
- Betting on Your Feelings: The Interplay between Emotion and Cognition in Gambling Affective Task.Journal of clinical medicine · 2024Article
- Loss, gain and choice difficulty in gambling patients: Neural and behavioural processes.Addiction biology · 2024Article
- The neural basis of delayed gratification.Science advances · 2021Article
- Article
- Impulse Control Disorders in Parkinson's Disease: Epidemiology, Pathogenesis and Therapeutic Strategies.Frontiers in psychiatry · 2021Review
- Autistic traits in young adults who gamble.CNS spectrums · 2020Article
- Cold pressor pain and gambling disorder: implications for the opioid system.CNS spectrums · 2020Article
- Abnormalities of striatal morphology in gambling disorder and at-risk gambling.CNS spectrums · 2019Article
- To chase or not to chase: A study on the role of mentalization and alcohol consumption in chasing behavior.Journal of behavioral addictions · 2019Article
- A Psychophysiological and Behavioural Study of Slot Machine Near-Misses Using Immersive Virtual Reality.Journal of gambling studies · 2019Article
- The interplay between chasing behavior, time perspective, and gambling severity: An experimental study.Journal of behavioral addictions · 2019Article
- A transdiagnostic dimensional approach towards a neuropsychological assessment for addiction: an international Delphi consensus study.Addiction (Abingdon, England) · 2019Article
- Cognitive Control and Criminogenic Cognitions in South Asian Gamblers.Journal of gambling studies · 2019Article
- Cued for risk: Evidence for an incentive sensitization framework to explain the interplay between stress and anxiety, substance abuse, and reward uncertainty in disordered gambling behavior.Cognitive, affective & behavioral neuroscience · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledIn problem gamblers, diminished cognitive control and increased impulsivity is present compared to healthy controls. Moreover, impulsivity has been found to be a vulnerability marker for the development of pathological gambling (PG) and problem gambling (PrG) and to be a predictor of relapse. In this review, the most recent findings on functioning of the brain circuitry relating to impulsivity and cognitive control in PG and PrG are discussed. Diminished functioning of several prefrontal areas and of the anterior cingulate cortex (ACC) indicate that cognitive-control related brain circuitry functions are diminished in PG and PrG compared to healthy controls. From the available cue reactivity studies on PG and PrG, increased responsiveness towards gambling stimuli in fronto-striatal reward circuitry and brain areas related to attentional processing is present compared to healthy controls. At this point it is unresolved whether PG is associated with hyper- or hypo-activity in the reward circuitry in response to monetary cues. More research is needed to elucidate the complex interactions for reward responsivity in different stages of gambling and across different types of reward. Conflicting findings from basic neuroscience studies are integrated in the context of recent neurobiological addiction models. Neuroscience studies on the interface between cognitive control and motivational processing are discussed in light of current addiction theories. CLINICAL IMPLICATIONS: We suggest that innovation in PG therapy should focus on improvement of dysfunctional cognitive control and/or motivational functions. The implementation of novel treatment methods like neuromodulation, cognitive training and pharmacological interventions as add-on therapies to standard treatment in PG and PrG, in combination with the study of their effects on brain-behavior mechanisms could prove an important clinical step forward towards personalizing and improving treatment results in PG.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.