ArticleFrontiers in systems neuroscience2014
Extraction and restoration of hippocampal spatial memories with non-linear dynamical modeling.
Article in Frontiers in systems neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Decoding Naturalistic Episodic Memory with Artificial Intelligence and Brain-Machine Interface.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- ReBaCCA-ss: Relevance-Balanced Continuum Correlation Analysis With Smoothing and Surrogating for Quantifying Similarity Between Population Spiking Activities.Neural computation · 2026Article
- Multi-Level Perception Systems in Fusion of Lifeforms: Classification, Challenges and Future Conceptions.Sensors (Basel, Switzerland) · 2026Review
- Distributed Temporal Coding of Visual Memory Categories in Human Hippocampal Neurons Revealed by an Interpretable Decoding Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Developing a hippocampal neural prosthetic to facilitate human memory encoding and recall of stimulus features and categories.Frontiers in computational neuroscience · 2024Article
- The anterior thalamic nuclei: core components of a tripartite episodic memory system.Nature reviews. Neuroscience · 2022Review
- A Double-Layer Multi-Resolution Classification Model for Decoding Spatiotemporal Patterns of Spikes With Small Sample Size.Neural computation · 2021Article
- Developing a hippocampal neural prosthetic to facilitate human memory encoding and recall.Journal of neural engineering · 2018Article
- Sparse Large-Scale Nonlinear Dynamical Modeling of Human Hippocampus for Memory Prostheses.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2018Article
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Authors and funding
6 authors.
Funding
Abstract
To build a cognitive prosthesis that can replace the memory function of the hippocampus, it is essential to model the input-output function of the damaged hippocampal region, so the prosthetic device can stimulate the downstream hippocampal region, e.g., CA1, with the output signal, e.g., CA1 spike trains, predicted from the ongoing input signal, e.g., CA3 spike trains, and the identified input-output function, e.g., CA3-CA1 model. In order for the downstream region to form appropriate long-term memories based on the restored output signal, furthermore, the output signal should contain sufficient information about the memories that the animal has formed. In this study, we verify this premise by applying regression and classification modelings of the spatio-temporal patterns of spike trains to the hippocampal CA3 and CA1 data recorded from rats performing a memory-dependent delayed non-match-to-sample (DNMS) task. The regression model is essentially the multiple-input, multiple-output (MIMO) non-linear dynamical model of spike train transformation. It predicts the output spike trains based on the input spike trains and thus restores the output signal. In addition, the classification model interprets the signal by relating the spatio-temporal patterns to the memory events. We have found that: (1) both hippocampal CA3 and CA1 spike trains contain sufficient information for predicting the locations of the sample responses (i.e., left and right memories) during the DNMS task; and more importantly (2) the CA1 spike trains predicted from the CA3 spike trains by the MIMO model also are sufficient for predicting the locations on a single-trial basis. These results show quantitatively that, with a moderate number of unitary recordings from the hippocampus, the MIMO non-linear dynamical model is able to extract and restore spatial memory information for the formation of long-term memories and thus can serve as the computational basis of the hippocampal memory prosthesis.
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