ArticleFrontiers in neuroanatomy2014
Three counting methods agree on cell and neuron number in chimpanzee primary visual cortex.
Article in Frontiers in neuroanatomy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45 citing papers in PubMed.
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- The influence of age and sex on the absolute cell numbers of the human brain cerebral cortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Control of complex behavior by astrocytes and microglia.Neuroscience and biobehavioral reviews · 2022Review
- Neuronal and non-neuronal scaling across brain regions within an intercross of domestic and wild chickens.Frontiers in neuroanatomy · 2022Article
- The large numbers of minicolumns in the primary visual cortex of humans, chimpanzees and gorillas are related to high visual acuity.Frontiers in neuroanatomy · 2022Article
- Bringing Anatomical Information into Neuronal Network Models.Advances in experimental medicine and biology · 2022Article
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- Two-photon GCaMP6f imaging of infrared neural stimulation evoked calcium signals in mouse cortical neurons in vivo.Scientific reports · 2021Article
- The number of neurons in Drosophila and mosquito brains.PloS one · 2021Article
- Individual and age-related variation of cellular brain composition in a squamate reptile.Biology letters · 2020Article
- The evolution of brain structure captured in stereotyped cell count and cell type distributions.Current opinion in neurobiology · 2020Review
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4 authors.
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Abstract
Determining the cellular composition of specific brain regions is crucial to our understanding of the function of neurobiological systems. It is therefore useful to identify the extent to which different methods agree when estimating the same properties of brain circuitry. In this study, we estimated the number of neuronal and non-neuronal cells in the primary visual cortex (area 17 or V1) of both hemispheres from a single chimpanzee. Specifically, we processed samples distributed across V1 of the right hemisphere after cortex was flattened into a sheet using two variations of the isotropic fractionator cell and neuron counting method. We processed the left hemisphere as serial brain slices for stereological investigation. The goal of this study was to evaluate the agreement between these methods in the most direct manner possible by comparing estimates of cell density across one brain region of interest in a single individual. In our hands, these methods produced similar estimates of the total cellular population (approximately 1 billion) as well as the number of neurons (approximately 675 million) in chimpanzee V1, providing evidence that both techniques estimate the same parameters of interest. In addition, our results indicate the strengths of each distinct tissue preparation procedure, highlighting the importance of attention to anatomical detail. In summary, we found that the isotropic fractionator and the stereological optical fractionator produced concordant estimates of the cellular composition of V1, and that this result supports the conclusion that chimpanzees conform to the primate pattern of exceptionally high packing density in V1. Ultimately, our data suggest that investigators can optimize their experimental approach by using any of these counting methods to obtain reliable cell and neuron counts.
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