Evidence map›Paper›PMID 24904210›Full record

ArticleInternational journal of nanomedicine2014

Osteogenic response of human mesenchymal stem cells to well-defined nanoscale topography in vitro.

Giuseppe Maria de Peppo, Hossein Agheli, Camilla Karlsson, Karin Ekström, Helena Brisby, Maria Lennerås, Stefan Gustafsson, Peter Sjövall, Anna Johansson, Eva Olsson and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. [The application of nanotopography in the development of tissue engineered tissues using mesenchymal stem cells].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2018
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Giuseppe Maria de PeppoThe New York Stem Cell Foundation Research Institute, New York, NY, USA ; Department of Biomaterials, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden ; BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, University of Gothenburg, Göteborg, Sweden.
Hossein AgheliDepartment of Biomaterials, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden ; BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, University of Gothenburg, Göteborg, Sweden.
Camilla KarlssonDepartment of Biomaterials, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden ; BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, University of Gothenburg, Göteborg, Sweden.
Karin EkströmDepartment of Biomaterials, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden ; BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, University of Gothenburg, Göteborg, Sweden.
Helena BrisbyBIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, University of Gothenburg, Göteborg, Sweden ; Department of Orthopaedics, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.
Maria LenneråsDepartment of Biomaterials, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden ; BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, University of Gothenburg, Göteborg, Sweden.
Stefan GustafssonBIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, University of Gothenburg, Göteborg, Sweden ; Applied Physics, Chalmers University of Technology, Göteborg, Sweden.
Peter SjövallBIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, University of Gothenburg, Göteborg, Sweden ; Applied Physics, Chalmers University of Technology, Göteborg, Sweden ; Chemistry, Materials and Surfaces, SP Technical Research Institute of Sweden, Borås, Sweden.
Anna JohanssonDepartment of Biomaterials, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden ; BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, University of Gothenburg, Göteborg, Sweden.
Eva OlssonBIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, University of Gothenburg, Göteborg, Sweden ; Applied Physics, Chalmers University of Technology, Göteborg, Sweden.
Jukka LausmaaBIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, University of Gothenburg, Göteborg, Sweden ; Chemistry, Materials and Surfaces, SP Technical Research Institute of Sweden, Borås, Sweden.
Peter ThomsenDepartment of Biomaterials, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden ; BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, University of Gothenburg, Göteborg, Sweden.
Sarunas PetronisBIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, University of Gothenburg, Göteborg, Sweden ; Chemistry, Materials and Surfaces, SP Technical Research Institute of Sweden, Borås, Sweden.
University of Gothenburg · SEUniversity of Borås · SEChalmers University of Technology · SENew York Stem Cell Foundation · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatterning medical devices at the nanoscale level enables the manipulation of cell behavior and tissue regeneration, with topographic features recognized as playing a significant role in the osseointegration of implantable devices.

methodsIn this study, we assessed the ability of titanium-coated hemisphere-like topographic nanostructures of different sizes (approximately 50, 100, and 200 nm) to influence the morphology, proliferation, and osteogenic differentiation of human mesenchymal stem cells (hMSCs).

resultsWe found that the proliferation and osteogenic differentiation of hMSCs was influenced by the size of the underlying structures, suggesting that size variations in topographic features at the nanoscale level, independently of chemistry, can be exploited to control hMSC behavior in a size-dependent fashion.

conclusionOur studies demonstrate that colloidal lithography, in combination with coating technologies, can be exploited to investigate the cell response to well defined nanoscale topography and to develop next-generation surfaces that guide tissue regeneration and promote implant integration.

Indexed as

Absorption, PhysicochemicalCells, CulturedGuided Tissue RegenerationHumansMaterials TestingMesenchymal Stem CellsMolecular ImprintingOsteoblastsOsteogenesisParticle SizePhotographySurface PropertiesTissue EngineeringTitaniumTitaniumcell proliferationcolloidal lithographyhuman mesenchymal stem cellsimplantable materialsmineralizationnanotopographyosteogenic differentiation

Identifiers

PMID24904210
PMCPMC4039423
OpenAlexW2079659179

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.