ArticleMediators of inflammation2014
Stress-induced mast cell activation in glabrous and hairy skin.
Article in Mediators of inflammation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed.
- Morphometry of Mast Cells in the Tongue Tissues of the White Rats under Stress Conditions.Bulletin of experimental biology and medicine · 2026Article
- Pinosylvin: A Multifunctional Stilbenoid with Antimicrobial, Antioxidant, and Anti-Inflammatory Potential.Current issues in molecular biology · 2025Review
- Capsaicin: Emerging Pharmacological and Therapeutic Insights.Current issues in molecular biology · 2024Review
- Psychological Stress, Mast Cells, and Psoriasis-Is There Any Relationship?International journal of molecular sciences · 2021Review
- Neuroimmune connections between corticotropin-releasing hormone and mast cells: novel strategies for the treatment of neurodegenerative diseases.Neural regeneration research · 2021Review
- Neuroendocrine Factors in Melanoma Pathogenesis.Cancers · 2021Review
- Acral lentiginous melanoma: Basic facts, biological characteristics and research perspectives of an understudied disease.Pigment cell & melanoma research · 2021Review
- Ocular cicatricial pemphigoid (Review).Experimental and therapeutic medicine · 2020Review
- Immunological approaches and therapy in burns (Review).Experimental and therapeutic medicine · 2020Review
- Postanesthetic skin erythema due to succinylcholine versus atracurium.Experimental and therapeutic medicine · 2020Article
- Inflammatory marker alteration in response to systemic therapies in psoriasis.Experimental and therapeutic medicine · 2020Article
- Skin - a vast organ with immunological function (Review).Experimental and therapeutic medicine · 2020Review
- Cannabinoids in the Pathophysiology of Skin Inflammation.Molecules (Basel, Switzerland) · 2020Review
- Aspects concerning patient adherence to anti-TNFα therapy in psoriasis: A decade of clinical experience.Experimental and therapeutic medicine · 2019Article
- Association between personality type, affective distress profile and quality of life in patients with psoriasis vs. patients with cardiovascular disease.Experimental and therapeutic medicine · 2019Article
- Clinical, microbiological and oxidative stress evaluation of periodontitis patients treated with two regimens of systemic antibiotics, adjunctive to non-surgical therapy: A placebo-controlled randomized clinical trial.Experimental and therapeutic medicine · 2019Article
- Capsaicin: Physicochemical properties, cutaneous reactions and potential applications in painful and inflammatory conditions.Experimental and therapeutic medicine · 2019Review
- Therapeutic management with biological anti-TNF-α agent in severe psoriasis associated with chronic hepatitis B: A case report.Experimental and therapeutic medicine · 2019Article
- Psoriasis: Association of interleukin-17 gene polymorphisms with severity and response to treatment.Experimental and therapeutic medicine · 2019Review
- Phenotypic changes of lymphocyte populations in psoriasiform dermatitis animal model.Experimental and therapeutic medicine · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mast cells play a key role in modulation of stress-induced cutaneous inflammation. In this study we investigate the impact of repeated exposure to stress on mast cell degranulation, in both hairy and glabrous skin. Adult male Wistar rats were randomly divided into four groups: Stress 1 day (n = 8), Stress 10 days (n = 7), Stress 21 days (n = 6), and Control (n = 8). Rats in the stress groups were subjected to 2 h/day restraint stress. Subsequently, glabrous and hairy skin samples from animals of all groups were collected to assess mast cell degranulation by histochemistry and transmission electron microscopy. The impact of stress on mast cell degranulation was different depending on the type of skin and duration of stress exposure. Short-term stress exposure induced an amplification of mast cell degranulation in hairy skin that was maintained after prolonged exposure to stress. In glabrous skin, even though acute stress exposure had a profound stimulating effect on mast cell degranulation, it diminished progressively with long-term exposure to stress. The results of our study reinforce the view that mast cells are active players in modulating skin responses to stress and contribute to further understanding of pathophysiological mechanisms involved in stress-induced initiation or exacerbation of cutaneous inflammatory processes.
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