ArticleScience (New York, N.Y.)2014
The sheep genome illuminates biology of the rumen and lipid metabolism.
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Article in Science (New York, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 293 papers.
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293citing papers in PubMed
26.9field-weighted citation impact, top 1% of its field
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Who cites it
293 citing papers in PubMed, 554 citations in OpenAlex.
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- Identification of miR-320d as a Negative Regulator of Proliferation and Fatty Acid Synthesis via Targeting SCD in Ovine Tail Preadipocytes.Animals : an open access journal from MDPI · 2026Article
- From farm to lab: gene-edited sheep transforming bone research.JBMR plus · 2026Review
- Sheep erythrocyte potassium locus highlights MYADM family regulation of electroneutral potassium chloride cotransporters (KCC).BMC genomics · 2026Article
- Sex-specific multigenerational epigenetic responses to real-world chemical mixture exposure in an outbred sheep model.bioRxiv : the preprint server for biology · 2026Article
- Advances in Molecular Genetics and Breeding of Cattle, Sheep, and Goats.Animals : an open access journal from MDPI · 2026Article
- Preliminary Investigation on Salivary Enzymes of Massese Sheep.Animals : an open access journal from MDPI · 2026Article
- Evolution and Comparative Analysis of Sheep Reference Genomes: From Fragmented Assemblies to Telomere-to-Telomere Genomics.Biology · 2026Review
- Comparative Single-Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- An integrative multi-omics investigation into the influence of forage type on the volatile flavor profile of Ujumqin sheep mutton.Frontiers in veterinary science · 2026Article
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- Claudin and Rab proteins are key molecular components involved in coccidiosis resistance in Portuguese Merino sheep.Genetics, selection, evolution : GSE · 2025Article
- Review
- Mixed Outcomes in Recombination Rates After Domestication: Revisiting Theory and Data.Molecular ecology · 2025Review
- Integrating whole-genome resequencing data reveals adaptive selection signatures in sheep populations under extreme environments.BMC genomics · 2025Article
- A unified catalog of 14,062 microbial species reference genomes provides new insight into the gut microbiota in high-altitude mammals.Microbiome · 2025Article
- Conservation of Native Livestock Breeds in Russia: Current State and Promising Prospects.Animals : an open access journal from MDPI · 2025Review
- Elucidating the pathogenesis of rumen abnormal adipose deposition in high-concentrate fed Hu sheep through transcriptomic profiling.BMC veterinary research · 2025Article
233 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
72 authors at 18 institutions in 8 countries.
Yu Jiang *State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
Min Xie *BGI-Shenzhen, Shenzhen 518083, China.
Wenbin Chen *BGI-Shenzhen, Shenzhen 518083, China.
Richard TalbotEdiburgh Genomics, University of Edinburgh, Easter Bush, Midlothian EH 25 9RG, UK.
Jillian F MaddoxDepartment of Veterinary Science, University of Melbourne, Victoria 3010, Australia.
Thomas FarautINRA, Laboratoire de Génétique Cellulaire, UMR 444, Castanet-Tolosan F-31326, France.
Chunhua WuUtah State University, Logan, UT 84322-1435-1435, USA.
Donna M MuznyHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
Yuxiang LiBGI-Shenzhen, Shenzhen 518083, China.
Wenguang ZhangState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
Jo-Ann StantonDepartment of Anatomy, University of Otago, Dunedin 9054, New Zealand.
Rudiger BrauningAgResearch, Invermay Agricultural Centre, Mosgiel 9053, New Zealand.
Wesley C BarrisCSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.
Thibaut HourlierWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Bronwen L AkenWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Stephen M J SearleWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
David L AdelsonCSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.
Chao BianBGI-Shenzhen, Shenzhen 518083, China.
Graham R CamCSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.
Yulin ChenCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Shifeng ChengBGI-Shenzhen, Shenzhen 518083, China.
Udaya DeSilvaCSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.
Karen DixenDepartment of Biology, University of Copenhagen, DK-2100 Copenhagen Ø, Denmark.
Yang DongState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
Guangyi FanBGI-Shenzhen, Shenzhen 518083, China.
Ian R FranklinCSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.
Shaoyin FuInner Mongolia Agricultural University, Hohhot 010018, China.
Rui GuanBGI-Shenzhen, Shenzhen 518083, China.
Margaret A HighlandUSDA-ARS Animal Disease Research Unit, Pullman, WA 99164 USA.
Michael E HolderHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
Guodong HuangBGI-Shenzhen, Shenzhen 518083, China.
Aaron B InghamCSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.
Shalini N JhangianiHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
Divya KalraHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
Christie L KovarHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
Sandra L LeeHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
Weiqing LiuBGI-Shenzhen, Shenzhen 518083, China.
Xin LiuBGI-Shenzhen, Shenzhen 518083, China.
Changxin LuBGI-Shenzhen, Shenzhen 518083, China.
Tian LvBGI-Shenzhen, Shenzhen 518083, China.
Tittu MathewHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
Sean McWilliamCSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.
Moira MenziesCSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.
Shengkai PanBGI-Shenzhen, Shenzhen 518083, China.
David RobelinINRA, Laboratoire de Génétique Cellulaire, UMR 444, Castanet-Tolosan F-31326, France.
Bertrand ServinINRA, Laboratoire de Génétique Cellulaire, UMR 444, Castanet-Tolosan F-31326, France.
David TownleyCSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.
Wenliang WangBGI-Shenzhen, Shenzhen 518083, China.
Bin WeiBGI-Shenzhen, Shenzhen 518083, China.
Stephen N WhiteUSDA-ARS Animal Disease Research Unit, Pullman, WA 99164 USA.
Xinhua YangBGI-Shenzhen, Shenzhen 518083, China.
Chen YeBGI-Shenzhen, Shenzhen 518083, China.
Yaojing YueLanzhou Institute of Husbandry and Pharmaceutical Science, Lanzhou,730050,China.
Peng ZengBGI-Shenzhen, Shenzhen 518083, China.
Qing ZhouBGI-Shenzhen, Shenzhen 518083, China.
Jacob B HansenDepartment of Biology, University of Copenhagen, DK-2100 Copenhagen Ø, Denmark.
Karsten KristensenDepartment of Biology, University of Copenhagen, DK-2200 Copenhagen N, Denmark.
Richard A GibbsHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
Paul FlicekEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom.
Christopher C WarkupBiosciences KTN, The Roslin Institute, Easter Bush, Midlothian, EH25 9RG, UK.
Huw E JonesBiosciences KTN, The Roslin Institute, Easter Bush, Midlothian, EH25 9RG, UK.
V Hutton OddySchool of Environmental and Rural Science, University of New England, Armidale, NSW 2351, Australia.
Frank W NicholasFaculty of Veterinary Science, University of Sydney, NSW 2006, Australia.
John C McEwanAgResearch, Invermay Agricultural Centre, Mosgiel 9053, New Zealand.
James KijasCSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.
Jun WangBGI-Shenzhen, Shenzhen 518083, China.
Kim C WorleyHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
Alan L ArchibaldThe Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush, Midlothian EH 25 9RG, UK.
Noelle CockettUtah State University, Logan, UT 84322-1435-1435, USA.
Xun XuBGI-Shenzhen, Shenzhen 518083, China.
Wen WangState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
Brian P DalrympleCSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.
BGI Group (China) · CNBaylor College of Medicine · USUniversity of Copenhagen · DKAgResearch · NZChinese Academy of Sciences · CNKunming Institute of Zoology · CNWashington State University · USWellcome Sanger Institute · GBEuropean Bioinformatics Institute · GBInner Mongolia Agricultural University · CNKing Abdulaziz University · SANorthwest A&F University · CNRoslin Institute · GBSichuan Agricultural University · CNThe University of Sydney · AUUniversity of New England · AUUniversity of Otago · NZWellcome Trust · GB
Funding
The Human Genome Sequencing CenterU54HG003273 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2004 to 2015
$341.3MBiotechnology and Biological Sciences Research Council BB/1025360/1Biotechnology and Biological Sciences Research Council BB/I025328/1Biotechnology and Biological Sciences Research Council BB/I025360/1Biotechnology and Biological Sciences Research Council BB/I025506/1Biotechnology and Biological Sciences Research Council BBS/E/D/05191130Biotechnology and Biological Sciences Research Council BBS/E/D/20211550Biotechnology and Biological Sciences Research Council BBS/E/D/20211552NHGRI NIH HHS U54 HG003273Wellcome Trust 095908Wellcome Trust 098051
Abstract
Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form of wool and represent a distinct class of animals that have a specialized digestive organ, the rumen, that carries out the initial digestion of plant material. We have developed and analyzed a high-quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lipid metabolism that had been amplified and/or had altered tissue expression patterns. This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals.
Indexed as
Amino Acid SequenceAnimalsFatty Acids, VolatileGene Expression RegulationGenomeKeratins, Hair-SpecificLipid MetabolismMolecular Sequence DataPhylogenyRumenSheep, DomesticTranscriptomeWoolFatty Acids, VolatileKeratins, Hair-Specific
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