ArticleJournal of the American Society of Nephrology : JASN2015
Renin lineage cells repopulate the glomerular mesangium after injury.
Article in Journal of the American Society of Nephrology : JASN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 73 citations in OpenAlex.
- Targeting liver angiotensinogen with siRNA enhances podocyte regeneration through renin lineage cells in experimental kidney disease.Molecular therapy. Nucleic acids · 2026Article
- A Possible Link between Cell Plasticity and Renin Expression in the Collecting Duct: A Narrative Review.International journal of molecular sciences · 2024Review
- Hold the salt for kidney regeneration.The Journal of clinical investigation · 2024Article
- SGLT2 inhibition promotes glomerular repopulation by cells of renin lineage in experimental kidney disease.Acta physiologica (Oxford, England) · 2024Article
- Cells of the renin lineage promote kidney regeneration post-release of ureteral obstruction in neonatal mice.Acta physiologica (Oxford, England) · 2023Article
- NEF-Induced HIV-Associated Nephropathy Through HCK/LYN Tyrosine Kinases.The American journal of pathology · 2023Article
- Editorial: Recent advances on renoprotection and kidney regeneration.Frontiers in physiology · 2023Article
- Implications of the Essential Role of Small Molecule Ligand Binding Pockets in Protein-Protein Interactions.The journal of physical chemistry. B · 2022Article
- Flexible and multifaceted: the plasticity of renin-expressing cells.Pflugers Archiv : European journal of physiology · 2022Review
- Potential renal stem/progenitor cells identified by in vivo lineage tracing.American journal of physiology. Renal physiology · 2022Review
- A quantitative 3D intravital look at the juxtaglomerular renin-cell-niche reveals an individual intra/extraglomerular feedback system.Frontiers in physiology · 2022Article
- Patterns of differentiation of renin lineage cells during nephrogenesis.American journal of physiology. Renal physiology · 2021Article
- Renin Cells, the Kidney, and Hypertension.Circulation research · 2021Review
- Deciphering the Identity of Renin Cells in Health and Disease.Trends in molecular medicine · 2021Review
- How can juxtaglomerular renin-producing cells support the integrity of glomerular endothelial cells?Pflugers Archiv : European journal of physiology · 2019Article
- Renin cells with defective Gsα/cAMP signaling contribute to renal endothelial damage.Pflugers Archiv : European journal of physiology · 2019Article
- Urinary Renin in Patients and Mice With Diabetic Kidney Disease.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Cells of NG2 lineage increase in glomeruli of mice following podocyte depletion.American journal of physiology. Renal physiology · 2018Article
- Pericytes in the renal vasculature: roles in health and disease.Nature reviews. Nephrology · 2018Review
- Lineage tracing aged mouse kidneys shows lower number of cells of renin lineage and reduced responsiveness to RAAS inhibition.American journal of physiology. Renal physiology · 2018Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
Mesangial cell injury has a major role in many CKDs. Because renin-positive precursor cells give rise to mesangial cells during nephrogenesis, this study tested the hypothesis that the same phenomenon contributes to glomerular regeneration after murine experimental mesangial injury. Mesangiolysis was induced by administration of an anti-mesangial cell serum in combination with LPS. In enhanced green fluorescent protein-reporter mice with constitutively labeled renin lineage cells, the size of the enhanced green fluorescent protein-positive area in the glomerular tufts increased after mesangial injury. Furthermore, we generated a novel Tet-on inducible triple-transgenic LacZ reporter line that allowed selective labeling of renin cells along renal afferent arterioles of adult mice. Although no intraglomerular LacZ expression was detected in healthy mice, about two-thirds of the glomerular tufts became LacZ positive during the regenerative phase after severe mesangial injury. Intraglomerular renin descendant LacZ-expressing cells colocalized with mesangial cell markers α8-integrin and PDGF receptor-β but not with endothelial, podocyte, or parietal epithelial cell markers. In contrast with LacZ-positive cells in the afferent arterioles, LacZ-positive cells in the glomerular tuft did not express renin. These data demonstrate that extraglomerular renin lineage cells represent a major source of repopulating cells for reconstitution of the intraglomerular mesangium after injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.