Evidence map›Paper›PMID 24904022›Full record

Trial reportJournal of lipid research2014

Replacing with whole grains and legumes reduces Lp-PLA2 activities in plasma and PBMCs in patients with prediabetes or T2D.

Minjoo Kim, Se Ri Jeung, Tae-Sook Jeong, Sang-Hyun Lee, Jong Ho Lee

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of lipid research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Minjoo KimNational Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition Yonsei University, Seoul, Korea Department of Food and Nutrition, Brain Korea 21 PLUS Project, Yonsei University, Seoul, Korea.
Se Ri JeungNational Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition Yonsei University, Seoul, Korea.
Tae-Sook JeongNational Research Laboratory of Lipid Metabolism and Atherosclerosis, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.
Sang-Hyun LeeDepartment of Family Practice, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea.
Jong Ho LeeNational Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition Yonsei University, Seoul, Korea Department of Food and Nutrition, Brain Korea 21 PLUS Project, Yonsei University, Seoul, Korea Department of Family Practice, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea College of Human Ecology, and Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Korea.
National Health Insurance Service · KRYonsei University · KRKorea Research Institute of Bioscience and Biotechnology · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To determine dietary effects on circulating lipoprotein-associated phospholipase A2 (Lp-PLA2) activity and enzyme activity in peripheral blood mononuclear cells (PBMCs), 99 patients with impaired fasting glucose, impaired glucose tolerance, or newly-diagnosed T2D were randomly assigned to either a control group (usual diet with refined rice) or the whole grain and legume group. Substitution of whole grains and legumes for refined rice was associated with the replacement of 7% of energy from carbohydrates with energy from protein (about 4%) and fat. After 12 weeks, the whole grain and legume group showed a significant decrease in fasting glucose, insulin, homeostasis model assessment-insulin resistance, hemoglobin A1c, malondialdehyde, plasma Lp-PLA2 activity, and oxidized LDL (ox-LDL), and an increase in LDL particle size. The changes (Δs) in these variables in the whole grain and legume group were significantly different from those in controls after adjustment for the baseline levels. When all subjects were considered, Δ plasma Lp-PLA2 positively correlated with Δ glucose, Δ PBMC Lp-PLA2, Δ ox-LDL, and Δ urinary 8-epi-prostaglandin F2α after being adjusted for confounding factors. The Δ PBMC Lp-PLA2 correlated positively with Δ glucose and Δ ox-LDL, and negatively with Δ LDL particle size and baseline PBMC Lp-PLA2 The substitution of whole grains and legumes for refined rice resulted in a reduction in Lp-PLA2 activities in plasma and PBMCs partly through improved glycemic control, increased consumption of protein relative to carbohydrate, and reduced lipid peroxides.

Indexed as

Diabetes Mellitus, Type 2FabaceaePrediabetic StateWhole Grains1-Alkyl-2-acetylglycerophosphocholine EsteraseFemaleHumansLeukocytes, MononuclearLipoproteins, LDLMaleMalondialdehydeMiddle Aged1-Alkyl-2-acetylglycerophosphocholine EsteraseLipoproteins, LDLMalondialdehydeoxidized low density lipoproteinPLA2G7 protein, humanlipoprotein-associated phospholipase A2peripheral blood mononuclear celltype 2 diabetes

Identifiers

PMID24904022
PMCPMC4109770
OpenAlexW2020337561

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.