Evidence map›Paper›PMID 24904021›Full record

ArticleThorax2014

Serum uric acid and the risk of respiratory disease: a population-based cohort study.

Laura J Horsfall, Irwin Nazareth, Irene Petersen

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Thorax, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 6 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 6 syntheses or guidelines pooled it, 94 citations in OpenAlex.

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  15. [Association between serum uric acid and airflow obstruction based on the health-checkup population].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2024
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  18. Analysis of the prognostic value of uric acid on the efficacy of immunotherapy in patients with primary liver cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Laura J HorsfallResearch Department of Primary Care and Population Health, Institute of Epidemiology and Health Care, University College London, London, UK.
Irwin NazarethResearch Department of Primary Care and Population Health, Institute of Epidemiology and Health Care, University College London, London, UK.
Irene PetersenResearch Department of Primary Care and Population Health, Institute of Epidemiology and Health Care, University College London, London, UK.
University College London · GB

Funding

Medical Research Council MR/K006584/1
6 · The paper itself

Abstract

introductionUric acid is the most abundant molecule with antioxidant properties found in human blood serum. We examined the relationship between serum uric acid and the incidence of respiratory disease including any effect modification by smoking status.

methodsA cohort with serum uric acid measured between 1 January 2000 and 31 December 2012 was extracted from The Health Improvement Network primary care research database. New diagnoses of COPD and lung cancer were ascertained based on diagnostic codes entered into the medical records.

resultsDuring 1 002 496 person years (PYs) of follow-up, there were 3901 COPD diagnoses and 1015 cases of lung cancer. After multivariable adjustment, strong interactions with smoking status were detected (p<0.001) for both outcomes with significant negative relationships between serum uric acid and respiratory disease for current smokers but no strong relationships for never-smokers or ex-smokers. The relationships were strongest for lung cancer in heavy smokers (≥20 cigarettes per day) with predicted incidence rates 97 per 10 000 PYs (95% CI 68 to 126) in the lowest serum uric acid quintile (100-250 µmol/L) compared with a predicted 28 per 10 000 PYs (95% CI 14 to 41) in the highest quintile (438-700 µmol/L).

conclusionsLow levels of serum uric acid are associated with higher rates of COPD and lung cancer in current smokers after accounting for conventional risk factors.

Indexed as

AdultAgedAged, 80 and overBiomarkersDisease ProgressionFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedPopulation SurveillanceRespiratory Tract DiseasesRetrospective StudiesUnited KingdomUric AcidBiomarkersUric AcidCOPD epidemiologyLung CancerOxidative StressTobacco and the lung

Identifiers

PMID24904021
PMCPMC4215274
OpenAlexW2142415957

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.