ArticleJournal of neuroinflammation2014
The association between sex-related interleukin-6 gene polymorphisms and the risk for cerebral palsy.
Article in Journal of neuroinflammation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 59 citations in OpenAlex.
- Erythropoietin Improves Poor Outcomes in Preterm Infants with Intraventricular Hemorrhage.CNS drugs · 2021Trial
- MRI patterns and clinical outcomes in cerebral palsy: insights from a large MRICS-based cohort.Journal of neurodevelopmental disorders · 2025Article
- The Association Study Between Cytokines and the Risk for Cerebral Palsy.Mediators of inflammation · 2025Article
- Association between Sex-RelatedJournal of clinical medicine · 2023Article
- Something Smells Fishy: How Lipid Mediators Impact the Maternal-Fetal Interface and Neonatal Development.Biomedicines · 2023Review
- Association of Nogo-A Gene Polymorphisms with Cerebral Palsy in Southern China: A Case-Control Study.Developmental neuroscience · 2023Article
- Cerebellar irradiation does not cause hyperactivity, fear, and anxiety-related disorders in the juvenile rat brain.European radiology experimental · 2022Article
- Article
- An association study of IL2RA polymorphisms with cerebral palsy in a Chinese population.BMC medical genomics · 2022Article
- Early factors associated with risk of developmental coordination disorder in very preterm children: A prospective area-based cohort study in Italy.Paediatric and perinatal epidemiology · 2022Article
- Article
- Immunological effects of cerebral palsy and rehabilitation exercises in children.Brain, behavior, & immunity - health · 2021Article
- Concentrations of fat-soluble nutrients and blood inflammatory compounds in mother-infant dyads at birth.Pediatric research · 2021Article
- Frequency distribution in intraoperative stimulation-evoked EMG responses during selective dorsal rhizotomy in children with cerebral palsy-part 2: gender differences and left-biased asymmetry.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Association Analysis of Interleukin-1β, Interleukin-6, and HMGB1 Variants with Postictal Serum Cytokine Levels in Children with Febrile Seizure and Generalized Epilepsy with Febrile Seizure Plus.Journal of clinical neurology (Seoul, Korea) · 2019Article
- Takayasu arteritis risk locus inAnnals of the rheumatic diseases · 2019Article
- Variants of the OLIG2 Gene are Associated with Cerebral Palsy in Chinese Han Infants with Hypoxic-Ischemic Encephalopathy.Neuromolecular medicine · 2019Article
- Autophagy-Related Gene 7 Polymorphisms and Cerebral Palsy in Chinese Infants.Frontiers in cellular neuroscience · 2019Article
- Neonatal Brain Injury and Genetic Causes of Adult-Onset Neurodegenerative Disease in Mice Interact With Effects on Acute and Late Outcomes.Frontiers in neurology · 2019Article
- Glutamate Transport and Preterm Brain Injury.Frontiers in physiology · 2019Review
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe relationship between genetic factors and the development of cerebral palsy (CP) has recently attracted much attention. Polymorphisms in the genes encoding proinflammatory cytokines have been shown to be associated with susceptibility to perinatal brain injury and development of CP. Interleukin-6 (IL-6) is a proinflammatory cytokine that plays a pivotal role in neonatal brain injury, but conflicting results have been reported regarding the association between IL-6 single nucleotide polymorphisms (SNPs) and CP. The purpose of this study was to analyze IL-6 gene polymorphisms and protein expression and to explore the role of IL-6 in the Chinese CP population.
methodsA total of 753 healthy controls and 713 CP patients were studied to detect the presence of five SNPs (rs1800796, rs2069837, rs2066992, rs2069840, and rs10242595) in the IL-6 locus. Of these, 77 healthy controls and 87 CP patients were selected for measurement of plasma IL-6 by Luminex assay. The SHEsis program was used to analyze the genotyping data. For all comparisons; multiple testing on each individual SNP was corrected by the SNPSpD program.
resultsThere were no differences in allele or genotype frequencies between the overall CP patients and controls among the five genetic polymorphisms. However, subgroup analysis found significant sex-related differences in allele and genotype frequencies. Differences were found between spastic CP and controls in males for rs2069837; between CP with periventricular leukomalacia and controls in males for rs1800796 and rs2066992; and between term CP and controls in males for rs2069837. Plasma IL-6 levels were higher in CP patients than in the controls, and this difference was more robust in full-term male spastic CP patients. Furthermore, the genotype has an effect on IL-6 synthesis.
conclusionsThe influence of IL-6 gene polymorphisms on IL-6 synthesis and the susceptibility to CP is related to sex and gestational age.
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