ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2014
Cellular and behavioral outcomes of dorsal striatonigral neuron ablation: new insights into striatal functions.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 31 citations in OpenAlex.
- Integrated transcriptomic and proteomic validation identifies SLC35D3 as a tumor-selective surface antigen for colorectal and neuroendocrine carcinomas.Biochemistry and biophysics reports · 2026Article
- Pathological cell assembly dynamics in a striatal MSN network model.Frontiers in computational neuroscience · 2024Article
- Positive symptom phenotypes appear progressively in "EDiPS", a new animal model of the schizophrenia prodrome.Scientific reports · 2021Article
- In utero exposure to protease inhibitor-based antiretroviral regimens delays growth and developmental milestones in mice.PloS one · 2020Article
- Enhanced Dopamine in Prodromal Schizophrenia (EDiPS): a new animal model of relevance to schizophrenia.NPJ schizophrenia · 2019Article
- The striatal cholinergic system in L-dopa-induced dyskinesias.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Synaptic plasticity may underlie l-DOPA induced dyskinesia.Current opinion in neurobiology · 2018Review
- ERK/MAPK Signaling Is Required for Pathway-Specific Striatal Motor Functions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Involvement of the bed nucleus of the stria terminalis in L-Dopa induced dyskinesia.Scientific reports · 2017Article
- Striatal D1 medium spiny neuron activation induces dyskinesias in parkinsonian mice.Movement disorders : official journal of the Movement Disorder Society · 2017Article
- Dopaminergic treatment weakens medium spiny neuron collateral inhibition in the parkinsonian striatum.Journal of neurophysiology · 2017Article
- Interaction between interleukin-1β and type-1 cannabinoid receptor is involved in anxiety-like behavior in experimental autoimmune encephalomyelitis.Journal of neuroinflammation · 2016Article
- SLC35D3 increases autophagic activity in midbrain dopaminergic neurons by enhancing BECN1-ATG14-PIK3C3 complex formation.Autophagy · 2016Article
- Review
- Robust presynaptic serotonin 5-HT(1B) receptor inhibition of the striatonigral output and its sensitization by chronic fluoxetine treatment.Journal of neurophysiology · 2015Article
- Article
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12 authors at 6 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
The striatum is the input structure of the basal ganglia network that contains heterogeneous neuronal populations, including two populations of projecting neurons called the medium spiny neurons (MSNs), and different types of interneurons. We developed a transgenic mouse model enabling inducible ablation of the striatonigral MSNs constituting the direct pathway by expressing the human diphtheria toxin (DT) receptor under the control of the Slc35d3 gene promoter, a gene enriched in striatonigral MSNs. DT injection into the striatum triggered selective elimination of the majority of striatonigral MSNs. DT-mediated ablation of striatonigral MSNs caused selective loss of cholinergic interneurons in the dorsal striatum but not in the ventral striatum (nucleus accumbens), suggesting a region-specific critical role of the direct pathway in striatal cholinergic neuron homeostasis. Mice with DT injection into the dorsal striatum showed altered basal and cocaine-induced locomotion and dramatic reduction of L-DOPA-induced dyskinesia in the parkinsonian condition. In addition, these mice exhibited reduced anxiety, revealing a role of the dorsal striatum in the modulation of behaviors involving an emotional component, behaviors generally associated with limbic structures. Altogether, these results highlight the implication of the direct striatonigral pathway in the regulation of heterogeneous functions from cell survival to regulation of motor and emotion-associated behaviors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.