ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2014
Prenatal cocaine exposure and adolescent neural responses to appetitive and stressful stimuli.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Alexithymia mediates white-matter microstructure and substance use escalation in trauma-exposed individuals.Journal of affective disorders · 2026Article
- An intergenerational lifespan perspective on the neuroscience of prenatal substance exposure.Pharmacology, biochemistry, and behavior · 2022Article
- Parenting in the Context of the Child: Genetic and Social Processes.Monographs of the Society for Research in Child Development · 2022Article
- Dopamine DDrug and alcohol dependence · 2021Article
- Movies and narratives as naturalistic stimuli in neuroimaging.NeuroImage · 2021Review
- Prenatal drug exposure from infancy through emerging adulthood: Results from neuroimaging.Drug and alcohol dependence · 2019Review
- Childhood trauma moderates inhibitory control and anterior cingulate cortex activation during stress.NeuroImage · 2019Article
- Substance-use initiation moderates the effect of stress on white-matter microstructure in adolescents.The American journal on addictions · 2018Article
- Feedback processing in adolescents with prenatal cocaine exposure: an electrophysiological investigation.Developmental neuropsychology · 2018Article
- Altered functional connectivity to stressful stimuli in prenatally cocaine-exposed adolescents.Drug and alcohol dependence · 2017Article
- White-matter crossing-fiber microstructure in adolescents prenatally exposed to cocaine.Drug and alcohol dependence · 2017Article
- Gender-related Differences in Inhibitory Control and Sustained Attention among Adolescents with Prenatal Cocaine Exposure.The Yale journal of biology and medicine · 2016Article
- Prenatal cocaine exposure, illicit-substance use and stress and craving processes during adolescence.Drug and alcohol dependence · 2016Article
- Childhood trauma and neural responses to personalized stress, favorite-food and neutral-relaxing cues in adolescents.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Blunted striatal responses to favorite-food cues in smokers.Drug and alcohol dependence · 2015Article
- How Relevant is Food Craving to Obesity and Its Treatment?Frontiers in psychiatry · 2014Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Preclinical research has demonstrated the effects of prenatal cocaine exposure (PCE) on brain regions involved in emotional regulation, motivational control, and addiction vulnerability-eg, the ventral striatum (VS), anterior cingulate (ACC), and prefrontal cortex (PFC). However, little is known about the function of these regions in human adolescents with PCE. Twenty-two adolescents with PCE and 22 age-, gender-, and IQ-matched non-cocaine exposed (NCE) adolescents underwent functional magnetic resonance imaging (fMRI) during exposure to individually personalized neutral/relaxing, stressful, and favorite-food cues. fMRI data were compared using group-level two-tailed t-tests in the BioImage Suite. In comparison with NCE adolescents, PCE adolescents had reduced activity within cortical and subcortical brain regions, including the VS, ACC, and medial and dorslolateral PFC during exposure to favorite-food cues but did not differ in neural responses to stress cues. Subjective food craving was inversely related to dorsolateral PFC activation among PCE adolescents. Among PCE adolescents, subjective anxiety ratings correlated inversely with activations in the orbitofrontal cortex and brainstem during the stress condition and with ACC, dorsolateral PFC, and hippocampus activity during the neutral-relaxing condition. Thus adolescents with PCE display hypoactivation of brain regions involved in appetitive processing, with subjective intensities of craving and anxiety correlating inversely with extent of activation. These findings suggest possible mechanisms by which PCE might predispose to the development of addictions and related disorders, eg, substance-use disorders and binge-eating.
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