ArticleDevelopment genes and evolution2014
Pan-metazoan phylogeny of the DMRT gene family: a framework for functional studies.
Article in Development genes and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Faster and smaller: Heterochronic shift in gene expression leads to larval onset of spermatogenesis and miniaturized males.iScience · 2026Article
- A panoramic view of the expression and function of the Doublesex/DMRT gene family inScience advances · 2026Article
- Comparative Genomics of Sex-Determination-Related Genes Reveals Shared Evolutionary Patterns Between Bivalves and Mammals, but Not Fruit Flies.Molecular ecology · 2025Article
- Sex-biased gene expression precedes sexual dimorphism in the agonadal annelid Platynereis dumerilii.Development (Cambridge, England) · 2025Article
- Identifying the sex chromosome and sex determination genes in the cattle tick, Rhipicephalus (Boophilus) microplus.G3 (Bethesda, Md.) · 2024Article
- Sex-biased gene expression precedes sexual dimorphism in the agonadal annelidbioRxiv : the preprint server for biology · 2024Article
- Article
- XY sex determination in a cnidarian.BMC biology · 2023Article
- Identification and functional analysis ofFrontiers in genetics · 2023Article
- Analyses of theFrontiers in physiology · 2023Article
- Integrated analysis of the miRNA and mRNA expression profiles in Leiocassis longirostris at gonadal maturation.Functional & integrative genomics · 2022Article
- Evolutionary History of Sexual Differentiation Mechanism in Insects.Molecular biology and evolution · 2022Article
- Cloning, expression, and function of the Spdmrt-like gene in Scylla paramamosain.Molecular biology reports · 2022Article
- High Polymorphism in theAnimals : an open access journal from MDPI · 2022Article
- A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.Nature ecology & evolution · 2022Article
- DMRT Transcription Factors in the Control of Nervous System Sexual Differentiation.Frontiers in neuroanatomy · 2022Review
- Evolution of sexual development and sexual dimorphism in insects.Current opinion in genetics & development · 2021Review
- Review
- Article
- Comparative Genomics Studies on theFrontiers in genetics · 2020Article
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3 authors.
Funding
Abstract
The family of Doublesex-Mab-3 Related Transcription factors (DMRTs) includes key regulators of sexual differentiation and neurogenesis. To help understand the functional diversification of this gene family, we examined DMRT gene complements from the whole genome sequences and predicted gene models of 32 animal species representing 12 different phyla and from several non-metazoan outgroups. DMRTs are present in all animals except the sponge Amphimedon queenslandica, but are not found in any of the outgroups, indicating that this gene family is specific to animals and has an ancient pre-eumetazoan origin. Our analyses suggest that DMRT genes diversified independently in bilaterian and non-bilaterian animals. Most clades in the DMRT gene tree, including those containing the well-characterized DMRT1 and doublesex genes, have phylogenetically limited distributions.
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