Evidence map›Paper›PMID 24903518›Full record

SynthesisJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2014

Mechanisms underlying the effect of acupuncture on cognitive improvement: a systematic review of animal studies.

Mason Chin Pang Leung, Ka Keung Yip, Yuen Shan Ho, Flora Ka Wai Siu, Wai Chin Li, Belinda Garner

Registry-linked trialAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05855421 (Efficacy and Safety of Auricular Acupuncture in Depression During the Covid 19 Pandemic), which is not on this map. Cited by 26 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 6 pooled it
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05855421 narecruitingnot on this mapstarted 2023, after this paper: background citation

Efficacy and Safety of Auricular Acupuncture in Depression During the Covid 19 Pandemic: a Multicenter Triple-blinded Randomized Clinical Trial

TypeinterventionalSponsorUniversidade do Sul de Santa CatarinaRan2023 to 2025Enrolled280ConditionsDepressive Symptoms, Depression, Anxiety, InsomniaArmsAuricular Acupuncture
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 6 syntheses or guidelines pooled it, 4 citations in OpenAlex.

  1. Pooled it
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  6. Acupuncture for depression.The Cochrane database of systematic reviews · 2018
    Pooled it
  7. Trial
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  14. Review
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  20. Electroacupuncture ameliorates cognitive impairment through inhibition of CaAcupuncture in medicine : journal of the British Medical Acupuncture Society · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Mason Chin Pang LeungDepartment of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, Special Administrative Region, China, mason.leung@polyu.edu.hk.
Ka Keung Yip
Yuen Shan Ho
Flora Ka Wai Siu
Wai Chin Li
Belinda Garner
Hong Kong Polytechnic University · HKEducation University of Hong Kong · HKMacau University of Science and Technology · MO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acupuncture has been reported to be beneficial in treating cognitive impairment in various pathological conditions. This review describes the effort to understand the signaling pathways that underlie the acupunctural therapeutic effect on cognitive function. We searched the literature in 12 electronic databases from their inception to November 2013, with full text available and language limited to English. Twenty-three studies were identified under the selection criteria. All recruited animal studies demonstrate a significant positive effect of acupuncture on cognitive impairment. Findings suggest acupuncture may improve cognitive function through modulation of signaling pathways involved in neuronal survival and function, specifically, through promoting cholinergic neural transmission, facilitating dopaminergic synaptic transmission, enhancing neurotrophin signaling, suppressing oxidative stress, attenuating apoptosis, regulating glycometabolic enzymes and reducing microglial activation. However, the quality of reviewed studies has room for improvement. Further high-quality animal studies with randomization, blinding and estimation of sample size are needed to strengthen the recognition of group differences.

Indexed as

Acupuncture TherapyAnimalsBrainCognition DisordersDisease Models, AnimalModels, NeurologicalSignal TransductionSynaptic Transmission

Identifiers

PMID24903518
OpenAlexW1570698375

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.