Evidence map›Paper›PMID 24903414›Full record

ArticleSchizophrenia bulletin2014

Comparison of the heritability of schizophrenia and endophenotypes in the COGS-1 family study.

Gregory Light, Tiffany A Greenwood, Neal R Swerdlow, Monica E Calkins, Robert Freedman, Michael F Green, Raquel E Gur, Ruben C Gur, Laura C Lazzeroni, Keith H Nuechterlein and 12 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia bulletin, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Computerized Assessment of Psychosis Risk.Journal of psychiatry and brain science · 2021
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Recent Advances in the Genetics of Schizophrenia.Molecular neuropsychiatry · 2018
    Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Gregory LightDepartment of Psychiatry, University of California San Diego, La Jolla, CA; VISN-22 Mental Illness, Research, Education and Clinical Center, San Diego Healthcare System La Jolla, CA; glight@ucsd.edu.
Tiffany A GreenwoodDepartment of Psychiatry, University of California San Diego, La Jolla, CA;
Neal R SwerdlowDepartment of Psychiatry, University of California San Diego, La Jolla, CA;
Monica E CalkinsDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA;
Robert FreedmanDepartment of Psychiatry, University of Colorado Health Sciences Center, Denver, CO;
Michael F GreenDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA; VA Greater Los Angeles Healthcare System, Los Angeles, CA;
Raquel E GurDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA;
Ruben C GurDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA;
Laura C LazzeroniDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA;
Keith H NuechterleinDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA;
Ann OlincyDepartment of Psychiatry, University of Colorado Health Sciences Center, Denver, CO;
Allen D RadantDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA; VA Puget Sound Health Care System, Seattle, WA;
Larry J SeidmanDepartment of Psychiatry, Harvard Medical School, Boston, MA; Massachusetts Mental Health Center Public Psychiatry, Division of the Beth Israel Deaconess Medical Center, Boston, MA;
Larry J SieverDepartment of Psychiatry, Mount Sinai School of Medicine, New York, NY; James J. Peters VA Medical Center, New York, NY;
Jeremy M SilvermanDepartment of Psychiatry, Mount Sinai School of Medicine, New York, NY; James J. Peters VA Medical Center, New York, NY;
Joyce SprockDepartment of Psychiatry, University of California San Diego, La Jolla, CA;
William S StoneDepartment of Psychiatry, Harvard Medical School, Boston, MA; Massachusetts Mental Health Center Public Psychiatry, Division of the Beth Israel Deaconess Medical Center, Boston, MA;
Catherine A SugarDepartment of Biostatistics, University of California, Los Angeles School of Public Health, Los Angeles, CA;
Debby W TsuangDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA; VA Puget Sound Health Care System, Seattle, WA;
Ming T TsuangDepartment of Psychiatry, University of California San Diego, La Jolla, CA; Center for Behavioral Genomics, Institute for Genomic Medicine, University of California San Diego, La Jolla, CA; Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, MA.
Bruce I TuretskyDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA;
David L BraffDepartment of Psychiatry, University of California San Diego, La Jolla, CA;

Funding

The Genetics of Endophenotypes and SchizophreniaR01MH065571 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRAFF, DAVID L. · 2003 to 2013
$7.0M
SENSORY GATING &HABITUATION IN SCHIZOPHRENIAR01MH042228 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRAFF, DAVID L. · 1987 to 2015
$6.5M
The Genetics of Endophenotypes and SchizophreniaR01MH065578 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 2003 to 2013
$4.2M
The Genetics of Endophenotypes and SchizophreniaR01MH065554 · NIMH · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SIEVER, LARRY J · 2003 to 2013
$4.1M
Genetics of Endophenotypes and SchizophreniaR01MH065558 · NIMH · UNIVERSITY OF WASHINGTON · PI TSUANG, DEBBY WEN · 2003 to 2013
$3.7M
The Genetics of Endophenotypes and SchizophreniaR01MH065707 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREEN, MICHAEL F. · 2003 to 2013
$3.6M
The Genetics of Endophenotypes and SchizophreniaR01MH065562 · NIMH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI SEIDMAN, LARRY J · 2003 to 2007
$2.6M
The Genetics of Endophenotypes and SchizophreniaR01MH065588 · NIMH · UNIVERSITY OF COLORADO DENVER · PI OLINCY, ANN · 2003 to 2007
$2.2M
SCHIZOPHRENIA--PSYCHOPATHOLOGY AND HETEROGENEITYR01MH043518 · NIMH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI SEIDMAN, LARRY J · 1998 to 2004
$1.8M
Pathway(s) From Genes to Functional Deficits of Schizophrenia PatientsR01MH079777 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LIGHT, GREGORY A · 2007 to 2010
$1.4M
SENSORY GATING AND HABITUATION IN SCHIZOPHRENIAR37MH042228 · NIMH · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI BRAFF, DAVID L. · 1993 to 2002
$1.3M
6/6 - The Genetics of Endophenotypes and SchizophreniaR01MH086135 · NIMH · STANFORD UNIVERSITY · PI LAZZERONI, LAURA C. · 2010 to 2013
$1.3M
NIMH NIH HHS K01 MH087889NIMH NIH HHS MH042228NIMH NIH HHS MH079777NIMH NIH HHS MH087889NIMH NIH HHS MH43518NIMH NIH HHS R01 MH042228NIMH NIH HHS R01 MH043518NIMH NIH HHS R01 MH065554NIMH NIH HHS R01-MH065554NIMH NIH HHS R01 MH065558NIMH NIH HHS R01 MH065562NIMH NIH HHS R01-MH065562NIMH NIH HHS R01 MH065571NIMH NIH HHS R01-MH065571NIMH NIH HHS R01 MH065578NIMH NIH HHS R01 MH065588NIMH NIH HHS R01 MH065707NIMH NIH HHS R01 MH079777NIMH NIH HHS R01 MH086135NIMH NIH HHS R01-MH65558NIMH NIH HHS R01-MH65578NIMH NIH HHS R01-MH65588NIMH NIH HHS R01-MH65707NIMH NIH HHS R37 MH042228NIMH NIH HHS R37 MH043518
6 · The paper itself

Abstract

backgroundTwin and multiplex family studies have established significant heritability for schizophrenia (SZ), often summarized as 81%. The Consortium on the Genetics of Schizophrenia (COGS-1) family study was designed to deconstruct the genetic architecture of SZ using neurocognitive and neurophysiological endophenotypes, for which heritability estimates ranged from 18% to 50% (mean = 30%). This study assessed the heritability of SZ in these families to determine whether there is a "heritability gap" between the diagnosis and related endophenotypes.

methodsNuclear families (N = 296) with a SZ proband, an unaffected sibling, and both parents (n = 1366 subjects; mean family size = 4.6) underwent comprehensive endophenotype and clinical characterization. The Family Interview for Genetic Studies was administered to all participants and used to obtain convergent psychiatric symptom information for additional first-degree relatives of interviewed subjects (N = 3304 subjects; mean family size = 11.2). Heritability estimates of psychotic disorders were computed for both nuclear and extended families.

resultsThe heritability of SZ was 31% and 44% for nuclear and extended families. The inclusion of bipolar disorder increased the heritability to 37% for the nuclear families. When major depression was added, heritability estimates dropped to 34% and 20% for nuclear and extended families, respectively.

conclusionsEndophenotypes and psychotic disorders exhibit comparable levels of heritability in the COGS-1 family sample. The ascertainment of families with discordant sibpairs to increase endophenotypic contrast may underestimate diagnostic heritability relative to other studies. However, population-based studies also report significantly lower heritability estimates for SZ. Collectively, these findings support the importance of endophenotype-based strategies and the dimensional view of psychosis.

Indexed as

EndophenotypesFamilyAdultFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedNuclear FamilyPsychotic DisordersSchizophreniabiomarkerscognitionendophenotypesheritabilitypsychosisschizophrenia

Identifiers

PMID24903414
PMCPMC4193725

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