Evidence map›Paper›PMID 24903386›Full record

ArticleClinical journal of the American Society of Nephrology : CJASN2014

Patient-stated preferences regarding volume-related risk mitigation strategies for hemodialysis.

Jennifer E Flythe, Thomas W Mangione, Steven M Brunelli, Gary C Curhan

Abstract readComparative StudyMulticenter Study
In one paragraph

Article in Clinical journal of the American Society of Nephrology : CJASN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Patient-Reported Outcome Instruments for Physical Symptoms Among Patients Receiving Maintenance Dialysis: A Systematic Review.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2015
    Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Patient Preferences for Longer or More Frequent In-Center Hemodialysis Regimens: A Multicenter Discrete Choice Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. The association between longer haemodialysis treatment times and hospitalization and mortality after the two-day break in individuals receiving three times a week haemodialysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2019
    Article
  13. Article
  14. Relative blood volume monitoring in hemodialysis patients: identifying its appropriate role.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2019
    Article
  15. Article
  16. Intradialytic hypotension, blood pressure changes and mortality risk in incident hemodialysis patients.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2018
    Observational
  17. Review
  18. Article
  19. Nephrologists' Perspectives on Defining and Applying Patient-Centered Outcomes in Hemodialysis.Clinical journal of the American Society of Nephrology : CJASN · 2017
    Article
  20. Ultrafiltration Rate and Mortality in Maintenance Hemodialysis Patients.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jennifer E FlytheRenal Division and Harvard Medical School, Boston, Massachusetts;
Thomas W MangioneHealth Services Division, John Snow, Inc., Boston, Massachusetts; and.
Steven M BrunelliRenal Division and DaVita Clinical Research, Minneapolis, Minnesota.
Gary C CurhanRenal Division and Harvard Medical School, Boston, Massachusetts; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts;

Funding

Harvard Clinical and Translational Science CenterKL2TR001100 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$8.5M
Sex-related differences in incidence rates of nephrolithiasisK24DK091417 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI CURHAN, GARY C. · 2011 to 2020
$1.5M
Unraveling the ultrafiltration rate--mortality association in dialysis patientsF32DK093159 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI FLYTHE, JENNIFER E · 2011 to 2012
$125k
NCATS NIH HHS 1KL2-TR001100-01NCATS NIH HHS KL2 TR001100NIDDK NIH HHS DK093159-02NIDDK NIH HHS DK91417NIDDK NIH HHS F32 DK093159NIDDK NIH HHS K24 DK091417
6 · The paper itself

Abstract

BACKGROUND AND

objectivesLarger weight gain and higher ultrafiltration rates have been associated with poorer outcomes among patients on dialysis. Dietary restrictions reduce fluid-related risk; however, adherence is challenging. Alternative fluid mitigation strategies include treatment time extension, more frequent dialysis, adjunct peritoneal dialysis, and wearable ultrafiltration devices. No data regarding patient preferences for fluid management exist. A survey was designed, tested, and administered to assess patient-stated preferences regarding fluid mitigation. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A written survey concerning fluid-related symptoms, patient and treatment characteristics, and fluid management preferences was developed. The cross-sectional survey was completed by 600 patients on hemodialysis at 18 geographically diverse ambulatory facilities. Comparisons of patient willingness to engage in volume mitigation strategies across fluid symptom burden, dietary restriction experience, and patient characteristics were performed.

resultsFinal analyses included 588 surveys. Overall, if allowed to liberalize fluid intake, 44.6% of patients were willing to extend treatment time by 15 minutes. Willingness to extend treatment time was incrementally less for longer treatment extensions; 12.2% of patients were willing to add a fourth weekly treatment session, and 13.5% of patients were willing to participate in nocturnal dialysis three nights per week. Patients more bothered by their fluid restrictions (versus less bothered) were more willing to engage in fluid mitigation strategies. Demographic characteristics and symptoms, such as cramping and dyspnea, were not consistently associated with willingness to engage in the proposed strategies. More than 25% of patients were unsure of their dry weights and typical interdialytic weight gains.

conclusionsPatients were generally averse to treatment time extension>15 minutes. Patients more bothered (versus less bothered) by their prescribed fluid restrictions were more willing to engage in volume mitigation strategies. Additional study of patient-stated preferences in hemodialysis treatment practices is needed to guide patient care and identify deficiencies in patient treatment and disease-related knowledge.

Indexed as

DrinkingPatient PreferenceWeight GainAdultAgedAmbulatory Care FacilitiesCross-Sectional StudiesHealth Care SurveysHealth Knowledge, Attitudes, PracticeHumansMiddle AgedPatient CompliancePrescriptionsRenal DialysisRisk AssessmentRisk FactorsESRDhemodialysisultrafiltration

Identifiers

PMID24903386
PMCPMC4123390

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.