ReviewCurrent hypertension reports2014
Genetics, ancestry, and hypertension: implications for targeted antihypertensive therapies.
Review in Current hypertension reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- The Association Between Stress-Induced Hyperglycemia Ratio and Increased Urinary Albumin Excretion in Patients With Hypertension: A Population-Based Study.The Kaohsiung journal of medical sciences · 2026Article
- Blood Pressure Polygenic Score Predicts Long-Term Blood Pressure Control and Treatment-Resistant Hypertension.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Zinc deficiency induces hypertension by paradoxically amplifying salt sensitivity under high salt intake in mice.Clinical and experimental nephrology · 2024Article
- Genes, environment, and African ancestry in cardiometabolic disorders.Trends in endocrinology and metabolism: TEM · 2023Review
- Association study ofFrontiers in genetics · 2023Article
- Antihypertensive Therapy and Incidence of Cancer.Journal of clinical medicine · 2022Article
- Visualizing novel connections and genetic similarities across diseases using a network-medicine based approach.Scientific reports · 2022Article
- Depression and hypertension awareness, treatment, and control in a multiethnic population in the Netherlands: HELIUS study.Internal and emergency medicine · 2021Article
- From heterogeneous healthcare data to disease-specific biomarker networks: A hierarchical Bayesian network approach.PLoS computational biology · 2021Article
- Association of Epoxide Hydrolase 2 Gene Arg287Gln with the Risk for Primary Hypertension in Chinese.International journal of hypertension · 2020Article
- Haploinsufficiency of ARHGAP42 is associated with hypertension.European journal of human genetics : EJHG · 2019Article
- Long-Term Effectiveness and Safety of SGLT-2 Inhibitors in an Italian Cohort of Patients with Type 2 Diabetes Mellitus.Journal of diabetes research · 2019Observational
- Natural selection and local adaptation of blood pressure regulation and their perspectives on precision medicine in hypertension.Hereditas · 2019Review
- The potential European genetic predisposition for non-contact anterior cruciate ligament injury.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2018Article
- Interactions of Genes and Sodium Intake on the Development of Hypertension: A Cohort-Based Case-Control Study.International journal of environmental research and public health · 2018Article
- ACE gene haplotypes and social networks: Using a biocultural framework to investigate blood pressure variation in African Americans.PloS one · 2018Article
- African ancestry is associated with facial melasma in women: a cross-sectional study.BMC medical genetics · 2017Article
- Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding.The Journal of clinical investigation · 2017Article
- Blood Pressure Control Provides Less Cardiovascular Protection in Adults With Than Without Apparent Treatment-Resistant Hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2016Article
- Neither self-reported ethnicity nor declared family origin are reliable indicators of genomic ancestry.Genetica · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Hypertension is the most common chronic condition seen by physicians in ambulatory care and a condition for which life-long medications are commonly prescribed. There is evidence for genetic factors influencing blood pressure variation in populations and response to medications. This review summarizes recent genetic discoveries that surround blood pressure, hypertension, and antihypertensive drug response from genome-wide association studies, while highlighting ancestry-specific findings and any potential implication for drug therapy targets. Genome-wide association studies have identified several novel loci for inter-individual variation of blood pressure and hypertension risk in the general population. Evidence from pharmacogenetic studies suggests that genes influence the blood pressure response to antihypertensive drugs, although results are somewhat inconsistent across studies. There is still much work that remains to be done to identify genes both for efficacy and adverse events of antihypertensive medications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.