Trial reportEuropean radiology2014
Effect of inspiration on airway dimensions measured in maximal inspiration CT images of subjects without airflow limitation.
Trial report in European radiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Effect of inspiratory lung volume on bronchial and arterial dimensions and ratios on chest computed tomography in patients with chronic obstructive pulmonary disease.European radiology · 2025Article
- Reproducibility of a combined artificial intelligence and optimal-surface graph-cut method to automate bronchial parameter extraction.European radiology · 2023Article
- Automatic airway segmentation from computed tomography using robust and efficient 3-D convolutional neural networks.Scientific reports · 2021Article
- The feasibility of navigation bronchoscopy-guided pulmonary microcoil localization of small pulmonary nodules prior to thoracoscopic surgery.Translational lung cancer research · 2020Article
- Long-term exposure to PMRespiratory research · 2020Article
- The Strain on Airway Smooth Muscle During a Deep Inspiration to Total Lung Capacity.Journal of engineering and science in medical diagnostics and therapy · 2019Article
- Elevation in lung volume and preventing catastrophic airway closure in asthmatics during bronchoconstriction.PloS one · 2018Article
- Diagnosis of bronchiectasis and airway wall thickening in children with cystic fibrosis: Objective airway-artery quantification.European radiology · 2017Article
- Localizing small lung lesions in video-assisted thoracoscopic surgery via radiofrequency identification marking.Surgical endoscopy · 2017Article
- The effect of disease and respiration on airway shape in patients with moderate persistent asthma.PloS one · 2017Article
- Is bronchial wall imaging affected by temporal resolution? comparative evaluation at 140 and 75 ms in 90 patients.European radiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo study the effect of inspiration on airway dimensions measured in voluntary inspiration breath-hold examinations.
methods961 subjects with normal spirometry were selected from the Danish Lung Cancer Screening Trial. Subjects were examined annually for five years with low-dose CT. Automated software was utilized to segment lungs and airways, identify segmental bronchi, and match airway branches in all images of the same subject. Inspiration level was defined as segmented total lung volume (TLV) divided by predicted total lung capacity (pTLC). Mixed-effects models were used to predict relative change in lumen diameter (ALD) and wall thickness (AWT) in airways of generation 0 (trachea) to 7 and segmental bronchi (R1-R10 and L1-L10) from relative changes in inspiration level.
resultsRelative changes in ALD were related to relative changes in TLV/pTLC, and this distensibility increased with generation (p < 0.001). Relative changes in AWT were inversely related to relative changes in TLV/pTLC in generation 3--7 (p < 0.001). Segmental bronchi were widely dispersed in terms of ALD (5.7 ± 0.7 mm), AWT (0.86 ± 0.07 mm), and distensibility (23.5 ± 7.7%).
conclusionsSubjects who inspire more deeply prior to imaging have larger ALD and smaller AWT. This effect is more pronounced in higher-generation airways. Therefore, adjustment of inspiration level is necessary to accurately assess airway dimensions. KEY POINTS: Airway lumen diameter increases and wall thickness decreases with inspiration. The effect of inspiration is greater in higher-generation (more peripheral) airways. Airways of generation 5 and beyond are as distensible as lung parenchyma. Airway dimensions measured from CT should be adjusted for inspiration level.
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