ArticleEuropean radiology2014
Spectral CT evaluation of interstitial brachytherapy in pancreatic carcinoma xenografts: preliminary animal experience.
Article in European radiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 23 citations in OpenAlex.
- Photon-counting CT in cancer radiotherapy: technological advances and clinical benefits.Physics in medicine and biology · 2025Review
- Quantitative parameters in novel spectral computed tomography: Assessment of Ki-67 expression in patients with gastric adenocarcinoma.World journal of gastroenterology · 2023Article
- Dual-energy CT may predict post-operative recurrence in early-stage glottic laryngeal cancer: a novel nomogram and risk stratification system.European radiology · 2022Article
- Development of a dual-energy spectral computed tomography-based nomogram for the preoperative discrimination of histological grade in colorectal adenocarcinoma patients.Journal of gastrointestinal oncology · 2021Article
- Preoperative normalized iodine concentration derived from spectral CT is correlated with early recurrence of hepatocellular carcinoma after curative resection.European radiology · 2021Article
- Development of a Nomogram Combining Clinical Risk Factors and Dual-Energy Spectral CT Parameters for the Preoperative Prediction of Lymph Node Metastasis in Patients With Colorectal Cancer.Frontiers in oncology · 2021Article
- The Value of TTPVI in Prediction of Microvascular Invasion in Hepatocellular Carcinoma.Cancer management and research · 2020Article
- Diagnostic accuracy of dual-energy CT-based nomograms to predict lymph node metastasis in gastric cancer.European radiology · 2018Article
- Detection of gastric cancer and its histological type based on iodine concentration in spectral CT.Cancer imaging : the official publication of the International Cancer Imaging Society · 2018Article
- Association between spectral computed tomography images and clinicopathological features in advanced gastric adenocarcinoma.Oncology letters · 2017Article
- Evaluation of rat C6 malignant glioma using spectral computed tomography.Experimental and therapeutic medicine · 2017Article
- Spectral computed tomography in advanced gastric cancer: Can iodine concentration non-invasively assess angiogenesis?World journal of gastroenterology · 2017Article
- CT spectral imaging for monitoring the therapeutic efficacy of VEGF receptor kinase inhibitor AG-013736 in rabbit VX2 liver tumours.European radiology · 2017Article
- Article
- Functional imaging of interstitial brachytherapy in pancreatic carcinoma xenografts using spectral CT: how does iodine concentration correlate with standardized uptake value of (18)FDG-PET-CT?The British journal of radiology · 2016Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe sought to evaluate the capability of spectral CT to detect the therapeutic response to (125)I interstitial brachytherapy in a pancreatic carcinoma xenograft nude mouse model.
methodsTwenty mice bearing SWl990 human pancreatic cancer cell xenografts were randomly separated into two groups: experimental (n = 10; 1.0 mCi) and control (n = 10; 0 mCi). After a two-week treatment, spectral CT was performed. Contrast-to-noise ratio (CNR) and iodine concentration (IC) in the lesions were measured and normalized to the muscle tissue, and nIC CD31 immunohistochemistry was used to measure microvessel density (MVD). The relationships between the nIC and MVD of the tumours were analysed.
resultsThe nIC of the experimental group was significantly lower than that of the control group during the multiphase examination. A significant difference in the MVD was observed between the two groups (P <0.001). The nIC values of the three-phase scans have a certain positive correlation with MVD (r = 0.57, p < 0.0001; r = 0.48, p = 0.002; r = 0.63, p = 0.0017 in the 10, 25, and 60 s phase, respectively).
conclusionsSpectral CT can be a useful non-invasive imaging modality in evaluating the therapeutic effect of (125)I interstitial brachytherapy to a pancreatic carcinoma. KEY POINTS: Spectral CT offers opportunities to assess therapeutic response in pancreatic cancer cases. Spectral CT findings correlated with vascular changes associated with (125)I seed implantation. Spectral CT with monochromatic imaging removed most (125)I seed artefacts.
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