ArticleDementia and geriatric cognitive disorders2014
Higher working memory predicts slower functional decline in autopsy-confirmed Alzheimer's disease.
Article in Dementia and geriatric cognitive disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Systematic review of strengths and limitations of randomized controlled trials for non-pharmacological interventions in mild cognitive impairment: focus on Alzheimer's disease.The journal of nutrition, health & aging · 2015Pooled it
- Semantic fluency predicts survival of memory clinic patients.Alzheimer's research & therapy · 2026Article
- Binaural Beat Stimulation Enhances Cognitive Function in Alzheimer's Disease via Temporal Lobe Activation: An sLORETA Study.Biomedicines · 2026Article
- Modulated theta band frequency with binaural beat stimulation correlates with improved cognitive scores in Alzheimer's patients.Frontiers in aging neuroscience · 2025Article
- Systematic characterization of a non-transgenic AβBiology of sex differences · 2023Article
- The cognitive and behavioral correlates of functional status in patients with frontotemporal dementia: A pilot study.Frontiers in human neuroscience · 2023Article
- Investigating the relationship between specific executive functions and functional decline among community-dwelling older adults: results from a prospective pilot study.BMC geriatrics · 2022Article
- Working memory assessment using cambridge neuropsychological test automated battery can help in the diagnosis of mild cognitive impairment: a systematic review and meta-analysis.Dementia & neuropsychologia · 2022Review
- Article
- The role of physical and cognitive function in performance of activities of daily living in patients with mild-to-moderate Alzheimer's disease - a cross-sectional study.BMC geriatrics · 2020Article
- Cloud-Based Brain Magnetic Resonance Image Segmentation and Parcellation System for Individualized Prediction of Cognitive Worsening.Journal of healthcare engineering · 2019Article
- Disease-related determinants are associated with mortality in dementia due to Alzheimer's disease.Alzheimer's research & therapy · 2018Article
- Effect and mechanism of oyster hydrolytic peptides on spatial learning and memory in mice.RSC advances · 2018Article
- Working memory test battery for young adults: Computerized working memory assessment.PloS one · 2017Article
- Impact of Alzheimer's Disease, Lewy Body and Vascular Co-Pathologies on Clinical Transition to Dementia in a National Autopsy Cohort.Dementia and geriatric cognitive disorders · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThere is heterogeneity in the pattern of early cognitive deficits in Alzheimer's disease (AD). However, whether the severity of initial cognitive deficits relates to different clinical trajectories of AD progression is unclear.
objectiveTo determine if deficits in specific cognitive domains at the initial visit relate to the rate of progression in clinical trajectories of AD dementia.
methods68 subjects from the National Alzheimer's Coordinating Center database who had autopsy-confirmed AD as the primary diagnosis and at least 3 serial assessments a year apart, with a Mini-Mental State Examination (MMSE) score >15 and a Clinical Dementia Rating Scale-Global (CDR-G) score ≤1 at the initial visit were included. A mixed regression model was used to examine the association between initial neuropsychological performance and rate of change on the MMSE and CDR Sum of Boxes.
resultsPreservation of working memory, but not episodic memory, in the mild cognitive impairment and early dementia stages of AD relates to slower rate of functional decline. DISCUSSION: These findings are relevant for estimating the rate of decline in AD clinical trials and in counseling patients and families. Improving working memory performance as a possible avenue to decrease the rate of functional decline in AD dementia warrants closer investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.