ArticleMolecular imaging and biology2014
Response to deep brain stimulation in the lateral hypothalamic area in a rat model of obesity: in vivo assessment of brain glucose metabolism.
Article in Molecular imaging and biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 1 of them a synthesis that pooled it.
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23 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Systematic review of rodent studies of deep brain stimulation for the treatment of neurological, developmental and neuropsychiatric disorders.Translational psychiatry · 2024Pooled it
- Unraveling the potential of hypothalamic deep brain stimulation for obesity: Impacts on memory, neuroplasticity and brain metabolism in the Zucker rat.Translational psychiatry · 2025Article
- Brain-Imaging Mechanisms on Female Abdominal Obesity Treated by "Shu-Mu" Acupoint Catgut Embedding and Compatibility Relation: Study Protocol for a 12-Week Randomized Controlled Trial.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- CerebralObesity (Silver Spring, Md.) · 2022Article
- Neuroimaging reveals distinct brain glucose metabolism patterns associated with morphine consumption in Lewis and Fischer 344 rat strains.Scientific reports · 2022Article
- The Poly I:C maternal immune stimulation model shows unique patterns of brain metabolism, morphometry, and plasticity in female rats.Frontiers in behavioral neuroscience · 2022Article
- A Characterization of the Effects of Minocycline Treatment During Adolescence on Structural, Metabolic, and Oxidative Stress Parameters in a Maternal Immune Stimulation Model of Neurodevelopmental Brain Disorders.The international journal of neuropsychopharmacology · 2021Article
- Exploratory study of the long-term footprint of deep brain stimulation on brain metabolism and neuroplasticity in an animal model of obesity.Scientific reports · 2021Article
- Article
- Effects of GABA and Leptin Receptor-Expressing Neurons in the Lateral Hypothalamus on Feeding, Locomotion, and Thermogenesis.Obesity (Silver Spring, Md.) · 2019Article
- Change in the Binding of [Molecular imaging and biology · 2019Article
- Assessment of Safety and Outcome of Lateral Hypothalamic Deep Brain Stimulation for Obesity in a Small Series of Patients With Prader-Willi Syndrome.JAMA network open · 2018Article
- Early neuromodulation prevents the development of brain and behavioral abnormalities in a rodent model of schizophrenia.Molecular psychiatry · 2018Article
- Neuromodulation for the treatment of eating disorders and obesity.Therapeutic advances in psychopharmacology · 2018Review
- Deep Brain Stimulation-Possible Treatment Strategy for Pathologically Altered Body Weight?Brain sciences · 2018Review
- Understanding Deep Brain Stimulation:BioMed research international · 2018Article
- Stimulating the nucleus accumbens in obesity: A positron emission tomography study after deep brain stimulation in a rodent model.PloS one · 2018Article
- Control of Food Intake by Gastrointestinal Peptides: Mechanisms of Action and Possible Modulation in the Treatment of Obesity.Journal of neurogastroenterology and motility · 2017Review
- Deep brain stimulation improves behavior and modulates neural circuits in a rodent model of schizophrenia.Experimental neurology · 2016Article
- DBS for Obesity.Brain sciences · 2016Review
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate changes in glucose brain metabolism after deep brain stimulation (DBS) in the lateral hypothalamic area (LHA) in a rat model of obesity. PROCEDURES: Ten obese male Zucker rats were divided into two groups: LHA-control and LHA-DBS. Concentric bipolar platinum-iridium electrodes were implanted bilaterally. After 7 days, DBS was applied for 15 days. Weight and food and water intake were monitored. 2-Deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) PET-CT imaging studies were performed the day after the end of DBS. Differences in glucose uptake between the groups were assessed with statistical parametric mapping.
resultsA difference in weight gain of 3.19 percentage points was found between groups. Average food consumption during the first 15 days was lower in DBS-treated animals than in non-stimulated animals. DBS increased metabolism in the mammillary body, subiculum-hippocampal area, and amygdala, while a decrease in metabolism was recorded in the thalamus, caudate, temporal cortex, and cerebellum.
conclusionsDBS produced significant changes in brain regions associated with the control of food intake and the brain reward system. DBS seems to normalize the impaired hippocampal functioning that has been described in obese rats. The smaller weight gain in the DBS group suggests that this technique could be considered an option for the treatment of obesity.
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