ArticlePediatric nephrology (Berlin, Germany)2014
Bone health in children and adolescents with steroid-sensitive nephrotic syndrome assessed by DXA and QUS.
Article in Pediatric nephrology (Berlin, Germany), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 35 citations in OpenAlex.
- Opportunistic screening for bone mineral density deficits in pediatric patients from abdominal computed tomography scans obtained for other indications: a cross-sectional study.Pediatric radiology · 2025Article
- Efficacy and safety of bisphosphonates in pediatric glucocorticoid-induced osteoporosis: a meta-analysis and pharmacovigilance study.Frontiers in pediatrics · 2025Article
- Changes in bone turnover markers after discontinuing long-term glucocorticoid administration in children with idiopathic nephrotic syndrome: a multicenter retrospective observational study.Pediatric nephrology (Berlin, Germany) · 2023Observational
- The use of quantitative ultrasound in a tertiary-level children hospital: role in the follow-up of chronically ill patients.Journal of ultrasound · 2022Article
- Developmental Abnormalities of Teeth in Children With Nephrotic Syndrome.International dental journal · 2022Article
- Mechanisms of Bone Impairment in Sickle Bone Disease.International journal of environmental research and public health · 2021Review
- Shedding "LIGHT" on the Link between Bone and Fat in Obese Children and Adolescents.International journal of molecular sciences · 2020Article
- Bone Health in Glomerular Kidney Disease.Current osteoporosis reports · 2019Review
- Irisin serum levels are positively correlated with bone mineral status in a population of healthy children.Pediatric research · 2019Article
- Assessment of the Concentration of Bone Metabolism Markers: Sclerostin and FGF-23 in Children with Idiopathic Nephrotic Syndrome Treated with Glucocorticosteroids.Disease markers · 2019Article
- Skeletal status assessment by quantitative ultrasound and bone densitometry in children with different renal conditions.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- Evaluation of bone mineralization in former preterm born children: Phalangeal quantitative ultrasound cannot replace dual-energy X-ray absorptiometry.Bone reports · 2018Article
- Assessment of Lactose-Free Diet on the Phalangeal Bone Mineral Status in Italian Adolescents Affected by Adult-Type Hypolactasia.Nutrients · 2018Article
- Effect of glucocorticoids on growth and bone mineral density in children with nephrotic syndrome.European journal of pediatrics · 2015Article
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7 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe management of steroid-sensitive nephrotic syndrome (SSNS) requires treatment with high-dose glucocorticoids (GCs), but GC usage causes the most frequent form of drug-induced osteoporosis. The aim of our study was to evaluate the impact of GCs on bone mineralization in patients with SSNS using two diagnostic tools, dual-energy X-ray densitometry (DXA) and quantitative ultrasound (QUS), and to compare the diagnostic efficacy of these two imaging tools.
methodsA total of 30 children with SSNS (age 5.20 ± 2.20 years) were evaluated at the start (T0) and after 1 (T1), 2.44 ± 0.75 (T2, 18 patients) and 5.96 ± 2.33 years (T4, 12 patients) of GC treatment. Patients who stopped at T2 were also evaluated at the 1-year timepoint after ceasing GC treatment (T3).
resultsOf the patients assessed at T2, 11 had bone mineralization at the lower limit of normal versus those at T0 and T1, with bone mineralization rescue at the 1-year timepoint after GC discontinuation. At T4, 6/12 patients had densitometric parameters at the lower limit of normal values, and 3/12 patients showed reduced bone mineralization. The parameters derived from measurements of DXA and QUS were significantly related to each timepoint.
conclusionsPatients with SSNS receiving GC therapy undergo bone status alteration related to the dosage and duration of the therapy. In terms of diagnostic efficacy, DXA and QUS were comparable, indicating that QUS is a reliable tool to evaluate bone health in children with SSNS.
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