Evidence map›Paper›PMID 24902858›Full record

SynthesisCancer medicine2014

A systematic review of microRNA expression profiling studies in human gastric cancer.

Sirjana Shrestha, Sheng-Da Hsu, Wei-Yun Huang, Hsi-Yuan Huang, WenLiang Chen, Shun-Long Weng, Hsien-Da Huang

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Cancer medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 1 synthesis or guideline pooled it, 146 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Research advances in the molecular classification of gastric cancer.Cellular oncology (Dordrecht, Netherlands) · 2024
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. The emerging role of miR-10 family in gastric cancer.Cell cycle (Georgetown, Tex.) · 2021
    Review
  15. Article
  16. Review
  17. emiRIT: a text-mining-based resource for microRNA information.Database : the journal of biological databases and curation · 2021
    Article
  18. Article
  19. Article
  20. Methylation as a critical epigenetic process during tumor progressions among Iranian population: an overview.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2021
    Review

31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sirjana ShresthaDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Sheng-Da Hsu
Wei-Yun Huang
Hsi-Yuan Huang
WenLiang Chen
Shun-Long Weng
Hsien-Da Huang
National Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer (GC) is the second leading cause of global cancer mortality. Most GC patients are diagnosed with advanced-stage disease and show extremely poor prognosis. All of the GC research has a common interest to search for the specific and sensitive biomarkers for early diagnosis of GC. Number of microRNAs play important role in GC. We carried out a systematic review of published miRNA profiling studies that compared the miRNA expression profiles between GC tissues and paired noncancerous gastric tissue. A vote-counting strategy was followed with the collection of information like total number of studies reporting differential expression of miRNA, total number of tissue samples used in the studies, direction of differential expression and fold change. A total of 352 differentially expressed microRNAs were reported in the 14 microRNA expression profiling studies that compared GC tissues with normal tissues with 120 microRNAs reported at least in two studies. In the group of consistently reported microRNAs, miR-21 was reported upregulated in 10 studies followed by miR-25, miR-92, and miR-223 upregulated in eight studies. MiR-375 and miR-148a were found downregulated in six and five studies, respectively, followed by miR-638 in four studies. MiR-107 and miR-103 were reported in nine and eight studies, respectively, but their expression were inconsistent. From this study, the most consistently reported upregulated microRNA was found to be miR-21. This systematic review study of human GC microRNA expression profiling studies would provide information on microRNAs with potential role as the biomarkers in gastric cancer.

Indexed as

TranscriptomeAnimalsBiomarkers, TumorEarly Detection of CancerGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMicroRNAsStomach NeoplasmsBiomarkers, TumorMicroRNAsBiomarkergastric cancermicroRNAmiRNA target genes

Identifiers

PMID24902858
PMCPMC4303155
OpenAlexW2018578236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.