Trial reportSurgical innovation2015
First experience on laparoscopic near-infrared fluorescence imaging of hepatic uveal melanoma metastases using indocyanine green.
Trial report in Surgical innovation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Application of indocyanine green-mediated fluorescence molecular imaging technology in liver tumors resection: a systematic review and meta-analysis.Frontiers in oncology · 2023Pooled it
- Clinical applications of indocyanine green fluorescence for the treatment of hepatocellular carcinoma.World journal of gastrointestinal oncology · 2026Review
- Review
- Review of Clinically Assessed Molecular Fluorophores for Intraoperative Image Guided Surgery.Molecules (Basel, Switzerland) · 2024Review
- Mechanisms of delayed indocyanine green fluorescence and applications to clinical disease processes.Surgery · 2024Review
- Preclinical evaluation of molecularly targeted fluorescent probes in perfused amputated human limbs.Journal of biomedical optics · 2023Article
- The Value of Indocyanine Green Image-Guided Surgery in Patients with Primary Liver Tumors and Liver Metastases.Life (Basel, Switzerland) · 2023Article
- Multimodal laparoscopic coincidence gamma imaging system for near-infrared fluorescence guided surgery: a preclinical study.Journal of medical imaging (Bellingham, Wash.) · 2023Article
- Near-Infrared Heptamethine Cyanine Dyes for Nanoparticle-Based Photoacoustic Imaging and Photothermal Therapy.Journal of medicinal chemistry · 2021Article
- Multispectral tissue mapping: developing a concept for the optical evaluation of liver disease.Journal of medical imaging (Bellingham, Wash.) · 2020Article
- Fluorescence-guided hepatobiliary surgery with long and short wavelength fluorophores.Hepatobiliary surgery and nutrition · 2020Review
- Comparison of manual and semi-automatic registration in augmented reality image-guided liver surgery: a clinical feasibility study.Surgical endoscopy · 2020Article
- The Application of Indocyanine Green Fluorescence Imaging During Robotic Liver Resection: A Case-Matched Study.World journal of surgery · 2019Article
- Review
- Improving the Surgical Effect for Primary Liver Cancer with Intraoperative Fluorescence Navigation Compared with Intraoperative Ultrasound.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Real-Time Navigation Guidance Using Fusion Indocyanine Green Fluorescence Imaging in Laparoscopic Non-Anatomical Hepatectomy of Hepatocellular Carcinomas at Segments 6, 7, or 8 (with Videos).Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Setting Standards for Reporting and Quantification in Fluorescence-Guided Surgery.Molecular imaging and biology · 2019Article
- A practical guide for the use of indocyanine green and methylene blue in fluorescence-guided abdominal surgery.Journal of surgical oncology · 2018Review
- Laparoscopic detection and resection of occult liver tumors of multiple cancer types using real-time near-infrared fluorescence guidance.Surgical endoscopy · 2017Article
- Vision 20/20: Molecular-guided surgical oncology based upon tumor metabolism or immunologic phenotype: Technological pathways for point of care imaging and intervention.Medical physics · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundUveal melanoma is the most common primary intraocular tumor in adults, and up to 50% of patients will develop liver metastases. Complete surgical resection of these metastases can improve 5-year survival, but only a few patients are eligible for radical surgical treatment. The aim of this study was to introduce a near-infrared (NIR) fluorescence laparoscope during minimally invasive surgery for intraoperative identification of uveal melanoma hepatic metastases and to use it to provide guidance during resection.
methodsThree patients diagnosed with one solitary liver metastasis from uveal melanoma are presented. Patients received 10 mg indocyanine green (ICG) intravenously 24 hours before surgery. A NIR fluorescence laparoscope was used to detect malignant liver lesions.
resultsIn all 3 patients, laparoscopic NIR fluorescence imaging using ICG successfully identified uveal melanoma metastases. In 2 patients, multiple additional lesions were identified by inspection and NIR fluorescence imaging, which were not identified by preoperative conventional imaging. In one patient, one additional lesion, not identified by computed tomography, magnetic resonance imaging, laparoscopic ultrasonography, and inspection, was observed with NIR fluorescence imaging only. Importantly, NIR fluorescence imaging provided guidance during resection of these metastases.
conclusionsWe describe the successful use of laparoscopic identification and resection of uveal melanoma liver metastases using NIR fluorescence imaging and ICG. This procedure is minimally invasive and should be used as complementary to conventional techniques for the detection and resection of liver metastases.
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