ArticleeLife2014
Salmonella Typhi and Salmonella Paratyphi A elaborate distinct systemic metabolite signatures during enteric fever.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Immunogenicity of a Bivalent Typhoid-Paratyphoid Conjugate Vaccine Against Diverse Salmonella Paratyphi A Isolates.The Journal of infectious diseases · 2026Trial
- The typhoid Mary legacy: Genomic epidemiology uncovers contemporary carriage dynamics across two decades of enteric fever surveillance in England and Wales.PLoS neglected tropical diseases · 2026Article
- Article
- Article
- Evolving Epidemiology and Antibiotic Resistance in Enteric Fever: A Comprehensive Review.Cureus · 2024Review
- FromACS omega · 2023Review
- Review
- Diagnostics for Typhoid Fever: Current Perspectives and Future Outlooks for Product Development and Access.Open forum infectious diseases · 2023Article
- Understanding the Mechanism of Antimicrobial Resistance and Pathogenesis ofMicroorganisms · 2022Review
- Chemical Composition and Biological Activities ofMolecules (Basel, Switzerland) · 2022Article
- Proteome-Based Serotyping of the Food-Borne PathogensMolecules (Basel, Switzerland) · 2022Article
- Enteric Fever Diagnosis: Current Challenges and Future Directions.Pathogens (Basel, Switzerland) · 2021Review
- Article
- The Current Status of Enteric Fever Diagnostics and Implications for Disease Control.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Article
- Typhoid fever: Control & challenges in India.The Indian journal of medical research · 2019Review
- Crosstalk between leukocytes triggers differential immune responses against Salmonella enterica serovars Typhi and Paratyphi.PLoS neglected tropical diseases · 2019Article
- Typhoid and paratyphoid fever: a call to action.Current opinion in infectious diseases · 2018Review
- Diagnostic metabolite biomarkers of chronic typhoid carriage.PLoS neglected tropical diseases · 2018Article
- Human genetic variation inProceedings of the National Academy of Sciences of the United States of America · 2017Article
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13 authors.
Funding
Abstract
The host-pathogen interactions induced by Salmonella Typhi and Salmonella Paratyphi A during enteric fever are poorly understood. This knowledge gap, and the human restricted nature of these bacteria, limit our understanding of the disease and impede the development of new diagnostic approaches. To investigate metabolite signals associated with enteric fever we performed two dimensional gas chromatography with time-of-flight mass spectrometry (GCxGC/TOFMS) on plasma from patients with S. Typhi and S. Paratyphi A infections and asymptomatic controls, identifying 695 individual metabolite peaks. Applying supervised pattern recognition, we found highly significant and reproducible metabolite profiles separating S. Typhi cases, S. Paratyphi A cases, and controls, calculating that a combination of six metabolites could accurately define the etiological agent. For the first time we show that reproducible and serovar specific systemic biomarkers can be detected during enteric fever. Our work defines several biologically plausible metabolites that can be used to detect enteric fever, and unlocks the potential of this method in diagnosing other systemic bacterial infections.
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