Evidence map›Paper›PMID 24902554›Full record

ArticleThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2014

Active case finding for tuberculosis among people who inject drugs on methadone treatment in Dar es Salaam, Tanzania.

A Gupta, J Mbwambo, I Mteza, S Shenoi, B Lambdin, C Nyandindi, B I Doula, S Mfaume, R D Bruce

Abstract read
In one paragraph

Article in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. A systematic review of the number needed to screen for active TB among people living with HIV.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2021
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Closing gaps in the tuberculosis care cascade: an action-oriented research agenda.Journal of clinical tuberculosis and other mycobacterial diseases · 2020
    Review
  7. Southern African HIV Clinicians Society guidelines for harm reduction.Southern African journal of HIV medicine · 2020
    Article
  8. The Opioid Epidemic in Africa And Its Impact.Current addiction reports · 2018
    Article
  9. Article
  10. Article
  11. Public health and international drug policy.Lancet (London, England) · 2016
    Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

A Gupta<label>*</label>Yale University School of Medicine, New Haven, Connecticut, USA.
J Mbwambo<label><sup>†</sup></label>Muhimbili University of Health and Allied Sciences, Dar es Salaam.
I Mteza<label><sup>‡</sup></label>Muhimbili National Hospital, Dar es Salaam.
S Shenoi<label>*</label>Yale University School of Medicine, New Haven, Connecticut, USA.
B Lambdin<label><sup>§</sup></label>Pangaea Global AIDS Foundation, Oakland, California, USA.
C Nyandindi<label><sup>†</sup></label>Muhimbili University of Health and Allied Sciences, Dar es Salaam.
B I Doula<label><sup>¶</sup></label>Central TB Reference Laboratory, Dar es Salaam, Tanzania.
S Mfaume<label><sup>¶</sup></label>Central TB Reference Laboratory, Dar es Salaam, Tanzania.
R D Bruce<label>*</label>Yale University School of Medicine, New Haven, Connecticut, USA.

Funding

Community-Based Intensive Case Finding for HIV, TB, and MDR/XDR TB in Rural SouthK23AI089260 · NIAID · YALE UNIVERSITY · PI SHENOI, SHEELA · 2011 to 2015
$668k
NIAID NIH HHS K23 AI089260
6 · The paper itself

Abstract

settingActive case finding is a World Health Organization (WHO) endorsed strategy for improving tuberculosis (TB) case detection. Despite WHO recommendations for active case finding among people who inject drugs (PWID), few studies have been published. The historical focus of case finding has been in populations that are human immunodeficiency virus-positive, incarcerated or at higher occupational risk.

objectiveWe sought to examine the yield of active case finding among PWID newly started on methadone in Tanzania.

designOf 222 methadone clients, 156 (70%) met with study administrators; 150 consented to participate, 139 (93%) of whom were male. The median age was 34 years. A symptom-based questionnaire was developed by the investigators and administered to every consenting patient by a native Swahili speaker.

resultsOf the 150 patients surveyed, 16 (11%) had one or more TB symptoms and were referred for laboratory testing. Six new TB cases were identified in this active case finding program, with a prevalence of 4%.

conclusionThis study presents the first data on TB prevalence in a population of PWID in Tanzania. This prevalence is 23 times that of the general Tanzanian TB prevalence of 0.2%. These results have significant implications for TB control.

Indexed as

AdultFemaleHumansMaleMethadonePrevalenceSubstance Abuse, IntravenousSurveys and QuestionnairesTanzaniaTuberculosisWorld Health OrganizationMethadone

Identifiers

PMID24902554
PMCPMC4506927

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.