Evidence map›Paper›PMID 24902553›Full record

ArticleThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2014

Interferon-gamma release assays piloted as a latent tuberculous infection screening tool in Canadian federal inmates.

I S Schwartz, P J Bach, B Roscoe, A Majury, W M Hopman, E Ellis, T Garrahan, J Smith, R Barkley, L Panaro and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. A Pilot TB Screening Model in a U.S. Prison Population Using Tuberculin Skin Test and Interferon Gamma Release Assay Based on Country of Origin.Journal of correctional health care : the official journal of the National Commission on Correctional Health Care · 2021
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

I S Schwartz<label>*</label>Departments of Medical Microbiology & Infectious Diseases and Internal Medicine, University of Manitoba, Winnipeg, Manitoba.
P J Bach<label><sup>†</sup></label>Department of Internal Medicine, University of British Columbia, Vancouver, British Columbia.
B Roscoe<label><sup>‡</sup></label>Correctional Services Canada, Health Services, Kingston, Ontario.
A Majury<label><sup>§</sup></label>Laboratory Services, Public Health Ontario, Kingston, Ontario.
W M Hopman<label><sup>#</sup></label>Clinical Research Centre, Kingston General Hospital, Kingston, Ontario.
E Ellis<label><sup>††</sup></label>Public Health Agency of Canada, Ottawa, Ontario.
T Garrahan<label><sup>‡</sup></label>Correctional Services Canada, Health Services, Kingston, Ontario.
J Smith<label><sup>‡</sup></label>Correctional Services Canada, Health Services, Kingston, Ontario.
R Barkley<label><sup>‡</sup></label>Correctional Services Canada, Health Services, Kingston, Ontario.
L Panaro<label><sup>‡</sup></label>Correctional Services Canada, Health Services, Kingston, Ontario.
F Jamieson<label><sup>§§</sup></label>Public Health Ontario, Laboratory Services, Toronto, Ontario.
C Froats<label><sup>§</sup></label>Laboratory Services, Public Health Ontario, Kingston, Ontario.
I Gemmill<label><sup>¶¶</sup></label>Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario.
W L Wobeser<label>**</label>Department of Public Health Sciences, Queen's University, Kingston, Ontario.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInterferon-gamma release assays (IGRAs) may be useful in diagnosing latent tuberculous infection (LTBI) in inmates; however, published experience in these settings is limited.

objectiveTo identify variables associated with IGRA positivity among Canadian federal inmates with positive tuberculin skin test (TST) results.

designOn intake, TST-positive (≥10 mm) inmates were offered an IGRA (QuantiFERON(®)-TB Gold), and demographic and historical data were collected. IGRA-positive and -negative inmates were compared using the χ(2) test and multivariable logistic regression; the final model's goodness of fit was assessed using Hosmer-Lemeshow test and area under the receiver operating characteristic curve (AUC).

resultsOf 96 TST-positive inmates, 31 (32.3%) were IGRA-positive. Variables associated with positive IGRA were age >45 years (11/20 vs. 20/75, P = 0.016) and previous LTBI treatment (9/20 vs. 13/55, P = 0.032) in univariate analysis, and being from a country with a moderate or high estimated tuberculosis (TB) incidence (OR 3.5, 95%CI 1.3-9.4, P = 0.013) and absence of bacille Calmette-Guérin (BCG) vaccination (OR 3.3, 95%CI 1.2-9.0, P = 0.017) in multivariable analysis. The data fit the model well, classifying the group better than chance alone (AUC 0.67, P = 0.007).

conclusionHigh discordance with TST, particularly among BCG-vaccinated inmates and those from low TB incidence countries, suggest that IGRA may be useful in Canadian federal penitentiary screening programmes.

Indexed as

Interferon-gamma Release TestsPrisonsAdultBCG VaccineCanadaHumansLatent TuberculosisLogistic ModelsMaleMass ScreeningMiddle AgedMultivariate AnalysisPilot ProjectsPrisonersTuberculin TestBCG Vaccine

Identifiers

PMID24902553

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.