Evidence map›Paper›PMID 24902542›Full record

ArticleHuman genetics2014

Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly.

Jonas Mengel-From, Mikael Thinggaard, Christine Dalgård, Kirsten Ohm Kyvik, Kaare Christensen, Lene Christiansen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 224 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
224citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

224 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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164 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jonas Mengel-FromEpidemiology, Biostatistics and Biodemography Unit, The Danish Aging Research Center, The Danish Twin Registry, Institute of Public Health, University of Southern Denmark, J.B. Winsløws Vej 9, 5000, Odense, Denmark, jmengel-from@health.sdu.dk.
Mikael Thinggaard
Christine Dalgård
Kirsten Ohm Kyvik
Kaare Christensen
Lene Christiansen

Funding

TRAJECTORIES OF MORTALITY IN CAENORHABDITIS ELEGANSP01AG008761 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI VAUPEL, JAMES W. · 1990 to 2008
$17.5M
THE RANGE OF MALE-FEMALE MORTALITY DIFFERENCESP01AG031719 · NIA · DUKE UNIVERSITY · PI VAUPEL, JAMES W. · 2009 to 2020
$10.2M
NIA NIH HHS P01 AG008761NIA NIH HHS P01 AG08761
6 · The paper itself

Abstract

The role of the mitochondria in disease, general health and aging has drawn much attention over the years. Several attempts have been made to describe how the numbers of mitochondria correlate with age, although with inconclusive results. In this study, the relative quantity of mitochondrial DNA compared to nuclear DNA, i.e. the mitochondrial DNA copy number, was measured by PCR technology and used as a proxy for the content of mitochondria copies. In 1,067 Danish twins and singletons (18-93 years of age), with the majority being elderly individuals, the estimated mean mitochondrial DNA copy number in peripheral blood cells was similar for those 18-48 years of age [mean relative mtDNA content: 61.0; 95 % CI (52.1; 69.9)], but declined by -0.54 mtDNA 95 % CI (-0.63; -0.45) every year for those older than approximately 50 years of age. However, the longitudinal, yearly decline within an individual was more than twice as steep as observed in the cross-sectional analysis [decline of mtDNA content: -1.27; 95 % CI (-1.71; -0.82)]. Subjects with low mitochondrial DNA copy number had poorer outcomes in terms of cognitive performance, physical strength, self-rated health, and higher all-cause mortality than subjects with high mitochondrial DNA copy number, also when age was controlled for. The copy number mortality association can contribute to the smaller decline in a cross-sectional sample of the population compared to the individual, longitudinal decline. This study suggests that high mitochondrial DNA copy number in blood is associated with better health and survival among elderly.

Indexed as

DNA Copy Number VariationsAdolescentAdultAgedAged, 80 and overAge FactorsAgingBody Mass IndexCross-Sectional StudiesDenmarkDNA, MitochondrialFemaleHumansLeukocytesLongitudinal StudiesMaleDNA, Mitochondrial

Identifiers

PMID24902542
PMCPMC4127366

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.