ArticlePloS one2014
Coriandrum sativum L. (Coriander) essential oil: antifungal activity and mode of action on Candida spp., and molecular targets affected in human whole-genome expression.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
68 citing papers in PubMed, 2 syntheses or guidelines pooled it, 181 citations in OpenAlex.
- Molecules and Metabolites from Natural Products as Inhibitors of Biofilm in Candida spp. pathogens.Current topics in medicinal chemistry · 2019Pooled it
- Antibacterial Activity of Essential Oils and Their Isolated Constituents against Cariogenic Bacteria: A Systematic Review.Molecules (Basel, Switzerland) · 2015Pooled it
- Salivary microbiome responses to chlorhexidine and Coriandrum sativum essential oil mouthwashes in patients with periodontitis in a randomized 2-week clinical trial.Clinical oral investigations · 2026Trial
- Synthetic Sinapates: Antifungal, Molecular Docking, and ADMET Studies.Chemistry & biodiversity · 2026Article
- Lipid-Based Drug Delivery Systems as Emerging Tools to Overcome Antifungal Resistance.International journal of molecular sciences · 2026Review
- The KW18 peptide acts as a dual antimicrobial and immunomodulatory therapeutic candidate in the context of antimicrobial resistance.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Coriander leaf essential oil as an immunomodulator: Enhancing NF-κB-driven RAW246.7 murine macrophages response to Candida albicans.PloS one · 2026Article
- Biocidal, antioxidant, and anti-inflammatory activities of essential oils extracted from Angelica spp. cultivated on contaminated soils.Scientific reports · 2025Article
- Isolation, Characterization, and Modes of Action of Antifungal Compounds from Rhizomes of Dryopteris nigropaleacea.Current microbiology · 2025Article
- Review
- Essential Oils as Alternative Green Broad-Spectrum Biocides.Plants (Basel, Switzerland) · 2024Review
- Article
- Antifungal activity against Candida albicans of methyl 3,5-dinitrobenzoate loaded nanoemulsion.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Growth, productivity and phytochemicals of Coriander in responses to foliar application of Acacia saligna fruit extract as a biostimulant under field conditions.Scientific reports · 2024Article
- Article
- A review of the bioactive properties of Mongolian plants, with a focus on their potential as natural food preservatives.Food science & nutrition · 2023Review
- Essential Oils: Chemistry and Pharmacological Activities.Biomolecules · 2023Review
- Current Understanding of the Molecular Basis of Spices for the Development of Potential Antimicrobial Medicine.Antibiotics (Basel, Switzerland) · 2023Review
- Essential Oil fromMolecules (Basel, Switzerland) · 2023Review
- Physiological responses and antioxidant properties of coriander plants (Coriandrum sativum L.) under different light intensities of red and blue lights.Scientific reports · 2022Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Oral candidiasis is an opportunistic fungal infection of the oral cavity with increasingly worldwide prevalence and incidence rates. Novel specifically-targeted strategies to manage this ailment have been proposed using essential oils (EO) known to have antifungal properties. In this study, we aim to investigate the antifungal activity and mode of action of the EO from Coriandrum sativum L. (coriander) leaves on Candida spp. In addition, we detected the molecular targets affected in whole-genome expression in human cells. The EO phytochemical profile indicates monoterpenes and sesquiterpenes as major components, which are likely to negatively impact the viability of yeast cells. There seems to be a synergistic activity of the EO chemical compounds as their isolation into fractions led to a decreased antimicrobial effect. C. sativum EO may bind to membrane ergosterol, increasing ionic permeability and causing membrane damage leading to cell death, but it does not act on cell wall biosynthesis-related pathways. This mode of action is illustrated by photomicrographs showing disruption in biofilm integrity caused by the EO at varied concentrations. The EO also inhibited Candida biofilm adherence to a polystyrene substrate at low concentrations, and decreased the proteolytic activity of Candida albicans at minimum inhibitory concentration. Finally, the EO and its selected active fraction had low cytotoxicity on human cells, with putative mechanisms affecting gene expression in pathways involving chemokines and MAP-kinase (proliferation/apoptosis), as well as adhesion proteins. These findings highlight the potential antifungal activity of the EO from C. sativum leaves and suggest avenues for future translational toxicological research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.