Evidence map›Paper›PMID 24901038›Full record

ArticleBiomacromolecules2014

Imparting superhydrophobicity to biodegradable poly(lactide-co-glycolide) electrospun meshes.

Jonah A Kaplan, Hongyi Lei, Rong Liu, Robert Padera, Yolonda L Colson, Mark W Grinstaff

Abstract read
In one paragraph

Article in Biomacromolecules, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jonah A KaplanDepartments of Biomedical Engineering and Chemistry, Boston University , Boston, Massachusetts 02215, United States.
Hongyi Lei
Rong Liu
Robert Padera
Yolonda L Colson
Mark W Grinstaff

Funding

Flexible, Conformal, Polymeric Films for Lung Resection MarginsR01CA149561 · NCI · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI COLSON, YOLONDA L, GRINSTAFF, MARK W. · 2011 to 2014
$1.4M
NCI NIH HHS R01 CA149561NCI NIH HHS R01CA149561
6 · The paper itself

Abstract

The synthesis of a family of new poly(lactic acid-co-glycerol monostearate) (PLA-PGC18) copolymers and their use as biodegradable polymer dopants is reported to enhance the hydrophobicity of poly(lactic acid-co-glycolic acid) (PLGA) nonwoven meshes. Solutions of PLGA are doped with PLA-PGC18 and electrospun to form meshes with micrometer-sized fibers. Fiber diameter, percent doping, and copolymer composition influence the nonwetting nature of the meshes and alter their mechanical (tensile) properties. Contact angles as high as 160° are obtained with 30% polymer dopant. Lastly, these meshes are nontoxic, as determined by an NIH/3T3 cell biocompatibility assay, and displayed a minimal foreign body response when implanted in mice. In summary, a general method for constructing biodegradable fibrous meshes with tunable hydrophobicity is described for use in tissue engineering and drug delivery applications.

Indexed as

Absorbable ImplantsAnimalsBiocompatible MaterialsElectrochemical TechniquesFemaleHydrophobic and Hydrophilic InteractionsMice, Inbred C57BLPolyglactin 910Surgical MeshTensile StrengthTissue EngineeringBiocompatible MaterialsPolyglactin 910

Identifiers

PMID24901038
PMCPMC4215912

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.