ReviewJournal of immunology research2014
The new insight into the role of antimicrobial proteins-alarmins in the immunopathogenesis of psoriasis.
Review in Journal of immunology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03149900 (Exploratory Evaluation of Biomarkers Associated With Treatment Response to Cosentyx), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exploratory Evaluation of Biomarkers Associated With Treatment Response to Cosentyx (Secukinumab) in Psoriasis Patients
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Polymorphism of VEGF gene in susceptibility to chronic immune-mediated inflammatory diseases: a meta-analysis.Rheumatology international · 2015Pooled it
- Crotonylation deficiency of S100A7 K49 promotes psoriatic keratinocyte proliferation through enhanced interaction with RAGE.Scientific reports · 2025Article
- Calcipotriol/Betamethasone Dipropionate for the Treatment of Psoriasis: Mechanism of Action and Evidence of Efficacy and Safety versus Topical Corticosteroids.Journal of clinical medicine · 2024Review
- Pathogenic role of S100 proteins in psoriasis.Frontiers in immunology · 2023Review
- S100 Proteins as Novel Therapeutic Targets in Psoriasis and Other Autoimmune Diseases.Molecules (Basel, Switzerland) · 2022Review
- Potential Pathogenetic Role of Antimicrobial Peptides Carried by Extracellular Vesicles in an in vitro Psoriatic Model.Journal of inflammation research · 2022Article
- Increased Serum Levels of S100A4 and S100A15 in Individuals Suffering from Hidradenitis Suppurativa.Journal of clinical medicine · 2021Article
- Predicted regulatory SNPs reveal potential drug targets and novel companion diagnostics in psoriasis.Journal of translational autoimmunity · 2021Article
- Skin - a vast organ with immunological function (Review).Experimental and therapeutic medicine · 2020Review
- Article
- Gut microbiota and nutrient interactions with skin in psoriasis: A comprehensive review of animal and human studies.World journal of clinical cases · 2020Review
- Alarmins HMGB1, IL-33, S100A7, and S100A12 in Psoriasis Vulgaris.Mediators of inflammation · 2020Article
- Adaptive and Innate Immunity in Psoriasis and Other Inflammatory Disorders.Frontiers in immunology · 2019Review
- C10orf99 contributes to the development of psoriasis by promoting the proliferation of keratinocytes.Scientific reports · 2018Article
- The Therapeutic Potential and Molecular Mechanism of Isoflavone Extract against Psoriasis.Scientific reports · 2018Article
- The Interleukin-23/Interleukin-17 Axis Links Adaptive and Innate Immunity in Psoriasis.Frontiers in immunology · 2018Review
- Role of MyD88 signaling in the imiquimod-induced mouse model of psoriasis: focus on innate myeloid cells.Journal of leukocyte biology · 2017Article
- Article
- [Pathogenesis of psoriasis].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2016Review
- Neutrophil/Lymphocyte Ratio, Serum Endocan, and Nesfatin-1 Levels in Patients with Psoriasis Vulgaris Undergoing Phototherapy Treatment.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathognesis of psoriasis still remains not fully elucidated. Recent advances favor the idea that interactions between innate and adaptive immune response drive inflammatory process in this disease. Innate antimicrobial peptides and proteins (AMPs) are diverse group of small molecules that provide the first line of defense against invading pathogens. In recent years, the novel functions of AMPs have been identified. There are three subclasses among AMPs that have gained the special interest as a potentially important player in the pathogenesis of psoriasis: cathelicidin, S100 proteins, and defensins. These AMPs have been shown to modulate and trigger host immune response in psoriasis acting as interplayer between innate and adaptive immune mechanisms. Overexpressed in psoriatic lesions, they prime immune cells for enhanced production of proinflammatory mediators and act as chemoattractant for leukocytes. Therefore, the novel term describing AMPs alarmins has been suggested. As multifunctional player in pathogenesis of psoriasis, AMPs may constitute potential target for therapeutic interventions. However, further investigations are required to establish the methods of downregulation of the aberrant proinflammatory functions of AMPs without increasing the risk of infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.