ArticleBioMed research international2014
Endothelium-independent vasorelaxant effects of hydroalcoholic extract from Nigella sativa seed in rat aorta: the roles of Ca2+ and K+ channels.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 44 citations in OpenAlex.
- Bisphenol A-Induced Vascular Endothelial Dysfunction: Protective Effects ofFood science & nutrition · 2025Article
- Medicinal plants administered to control hypertension in Ethiopia: ethnomedicine, pharmacology, nutraceutical, phytochemistry, toxicology, and policy perspectives.Frontiers in cardiovascular medicine · 2025Review
- Vasorelaxant effects of biochemical constituents of various medicinal plants and their benefits in diabetes.World journal of diabetes · 2024Review
- Spironolactone Induces Vasodilation by Endothelium-Dependent Mechanisms Involving NO and by Endothelium-Independent Mechanisms Blocking CaJournal of xenobiotics · 2024Article
- Antioxidant Properties and Vasorelaxant Mechanism of Aqueous ExtractBioMed research international · 2024Article
- Methanol (80%) leaf extract of Otostegia integrifolia Benth (Lamiaceae) lowers blood pressure in rats through interference with calcium conductance.BMC complementary medicine and therapies · 2021Article
- Review of Natural Resources With Vasodilation: Traditional Medicinal Plants, Natural Products, and Their Mechanism and Clinical Efficacy.Frontiers in pharmacology · 2021Review
- Vasorelaxant effect of water fraction ofInternational Journal of Cardiology. Hypertension · 2020Article
- The Possible Therapeutic Effects of Some Medicinal Plants for Chronic Cough in Children.Evidence-based complementary and alternative medicine : eCAM · 2020Review
- Effect ofThe Eurasian journal of medicine · 2018Article
- Extract fromAdvanced biomedical research · 2018Article
- Anti-hypertensive Herbs and their Mechanisms of Action: Part I.Frontiers in pharmacology · 2015Review
- The relaxant effect of Nigella sativa on smooth muscles, its possible mechanisms and clinical applications.Iranian journal of basic medical sciences · 2014Review
- The vasodilatory effect ofAvicenna journal of phytomedicineArticle
- Article
- Nigella sativa seed decreases endothelial dysfunction in streptozotocin-induced diabetic rat aorta.Avicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to elucidate the mechanism(s) responsible for the vasorelaxant effect of Nigella sativa (N. sativa).
methodsThe activity of different concentrations of N. sativa extract was evaluated on contractile responses of isolated aorta to KCl and phenylephrine (PE).
resultsThe extract (2-14 mg/mL) induced a concentration dependent relaxation both in endothelium-intact and endothelium-denuded aortic rings precontracted by PE (10(-6) M) and KCl (6 × 10(-2) M). Extract reduced PE- and KCl-induced contractions in presence of cumulative concentrations of calcium (10(-5)-10(-2) M) significantly. L-NAME and indomethacin had no effect on vasorelaxation effect of extract in PE-induced contraction. Diltiazem and heparin reduced significantly this vasorelaxation at a concentration of 14 mg/mL of extract; however, N. sativa-induced relaxation was not affected by ruthenium red. Tetraethylammonium chloride reduced the extract-induced relaxation in concentrations of 2-6 mg/mL of extract significantly but glibenclamide reduced this relaxative effect in all concentrations of extract.
conclusionsThe inhibitory effect of N. sativa seed extract on the contraction induced by PE and KCl was endothelium-independent. This relaxation was mediated mainly through the inhibition of Ca(2+) and KATP channels and also intracellular calcium release.
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